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Most movies don't know how to handle cancer. Heck, most people don't know how to handle cancer — and I'm not talking about the patients. Cancer, or any other terminal illness for that matter, almost always plays some kind x-factor in a film — that is when a film even dares to enter a realm often deemed depressing and "not for the movies." Most often, scripts will position cancer as a tearjerking emotional turning point in a film or as the initial spark of some banal "live life to the fullest" comedy.

"50/50" puts an end to that. Written semi-autobiographically by cancer survivor Will Reiser, it would seem it takes one to write one. Although cancer drives the entire story, the story doesn't fixate on cancer or melodramatize the terrible truths we already know about potentially fatal illness. Perhaps you could tell as much from the trailer thanks to some typical Seth Rogen antics, but the injection of contemporary R-rated humor is neither irreverent, insensitive nor an attempt to simply put a positive spin on a depressing subject. Life — believe it or not — doesn't stop for cancer. People don't sit in the hospital the entire time and then lie at home in bed the rest. Reiser's story provides a mostly unforced and honest depiction of a young man's diagnosis and treatment for potentially fatal spinal cancer, one where cancer isn't the conflict in and of itself, but the way it so dramatically changes the behavior of the people whose lives it enters and positively and negatively alters relationships.

Joseph Gordon-Levitt continues his spree of playing absolutely lovable main characters as Adam, a play-it-safe 27-year-old who after the initial shock handles his diagnosis in stride, keeping his ups and downs internal other than when the script cues him to let it out a bit. The more external symptoms come from Adam's girlfriend (Bryce Dallas Howard), best friend Kyle (Seth Rogen) and mother (Anjelica Huston).

Other than focusing on these relationships, director Jonathan Levine ("The Wackness") puts particular emphasis on character perspective, which will change instantaneously at points throughout the film. In one terrific sequence, Adam enters the hospital for his first chemo treatment and gets bummed out by all the sick and ailing people in the hallway. After the older men he meets while getting treatment (Philip Baker Hall and Matt Frewer) give him some marijuana-filled pastries, he leaves down the same hallway high as a kite, suddenly elated despite the same negative images lining the hall. Levine understands that so much of how you deal with cancer relates to mood and perspective at any given time.

Levine coaxes brilliant and thoughtful performances out of his actors. Even though Rogen exerted his usual shtick a bit more than needed, he handles his character as written, someone who wants desperately to help his best friend but hides behind shallow self-centered form of support that many men turn to because they can't communicate emotions all that well.

The women of "50/50" also deliver if not more so. Howard's character is an unlikable mess but she gives her performance convincingly. Anjelica Huston perfects the ideal on-screen mother, the best since Melissa Leo's Oscar-winning mother in "The Fighter." Anna Kendrick also continues to blow me away with her talent. She plays a psychiatrist working on her PhD who receives Adam as just her third patient. She gives such lifelike quirks to her characters and Katie plays right to her strengths.

But in a drama/comedy about cancer, the key lies in tone and for that Levine should become an A-list director. "50/50" could have easily turned into a Hollywood hack-job like the various comic-toned cancer films before it, a film that either overplays the dramatic or overcompensates with the humorous, but "50/50" might be one of film's best balancing acts between the two. The shifts feel completely natural between moments of deep sentiment and moments of levity. Those who can't help but fixate on this being a movie about cancer will likely have to remind themselves to feel serious when "50/50" just wants you to simply absorb it as you would any other film.

Other than some predictable moments and plot devices to give the film a nicer Hollywood sheen, "50/50" provides a genuine and heartfelt movie experience, one that neither goes for the emotional sucker punch nor the sugarcoated version. Instead of making us look at cancer in a specific way, it makes us look at the way we look at cancer — or any uncomfortable subject — the way we talk about it or don't talk about it, the way we interact with those who live with it and the way we cope with it ourselves. That way when someone we love has a serious problem, we can ultimately do what's best for that person.

~Steven C

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Adam (Gordon-Levitt) is a rule-following, mild-mannered twentysomething who lives in Seattle with his girlfriend, Rachael (Bryce Dallas-Howard), and works at Seattle Public Radio. His life takes a sudden and dramatic turn when he is diagnosed with a rare form of cancer that has taken over his spine. A laidback kind of guy, Adam handles each hurdle with surprising ease and levity while engaging in somewhat helpful counseling from Katie (Anna Kendrick), a young psychologist the hospital assigns him. Before long, though, his complex relationships with Rachael, his best friend Kyle (Seth Rogen), and his needy mother (Angelica Huston) become even more convoluted with the introduction of chemotherapy and medicinal marijuana into his life. As the severity of his condition increases, Adam begins to reassess his life, his relationships, and the nonplussed façade he uses to get himself through.

The inevitable comparisons between "50/50" and 2009's "Funny People" are unfortunate. While I stuck up for "Funny People" more than most of my colleagues, even I will admit it is an incredibly flawed film that misses the mark on many levels. "50/50", then, plays out a bit like what "Funny People" should have been, right down to the performance of Seth Rogen. It is, first and foremost, a very funny movie and that is where "Funny People" first went awry. You can't make a comedy about cancer, or any other serious illness for that matter, and fail to produce a genuinely funny script. Laughs come often and organically. I also quite liked that writer Will Reiser (who based his script on the events of his own battle with cancer) makes it clear early on that he intends to laugh at cancer and if you're not up for that, you're in the wrong theater. That is not to say that the disease itself or the havoc it wreaks on Adam's life is disrespected or ignored; in fact, "50/50" gives a fairly realistic view of the hell that is aggressive cancer and the sometimes even more aggressive treatment. "50/50" is bold but soft, a combination that works well.

The dialogue between the characters in "50/50" flows with tremendous ease, especially in the scenes involving Adam and Kyle. This dynamic between JGL and Rogen is the meat of the film and the two play it out brilliantly. They have a chemistry that Anne Hathaway only wishes she could develop with…well, anyone. (That was an unnecessary shot at Miss Hathaway. My apologies.) They reminded me of the type of friendship I might have with any one of my closer pals if we cursed more and occasionally smoked pot. Adam's other relationships are a bit awkward but whether this was done on purpose or not, it serves the narrative well. In my mind he would have a tense partnership with Rachael because they're clearly not suited for each other and any furtherance of his friendship with Katie beyond doctor-patient would be a bit odd.

All of the supporting actors hold their own. As spot-on as I might have been with JGL all those years ago, I would have never guessed, after reluctantly watching "Twilight", that Kendrick would be an actress whose performances I truly look forward to. This isn't quite to the level of her work in "Up in the Air" but it is good and believable nonetheless. Huston's character seems a bit over-the-top in the early going but the depth of her character comes to light in the late stages and Huston pulls it together splendidly. And Rogen gives what might be his best performance to date. To be fair, I'm not much of a Rogen fan so I'm far from an expert on his value as an actor. But whereas he was completely outclassed in "Funny People" and pretty much plays the same character in almost every film, he shows a little more strength in "50/50" than he ever has before (with the possible exception of "Knocked Up"). I actually liked him and I haven't felt that way toward him very often.

But of course, the weight of "50/50" rests almost entirely on the shoulders of JGL and he holds up to the challenge. One of the best compliments I can give an actor is to say that he and his character become one and the same. That's what JGL does here and that's why "50/50" succeeds. He envelopes himself into the Adam character and makes his portrayal incredibly believable. It is almost like watching a documentary on a young cancer patient. Adam handles his disease with class and dignity but not without emotion. His outbursts are few but powerful and through them JGL sells the story beautifully. Simply put, this guy is a star and "50/50" serves as the announcement of such to those of you who didn't already know this to be fact.

"50/50" is honest and at times tough to watch but never purposefully harsh or depressing. In fact, it is generally positive but in a way that isn't all sunshine and unicorns. It is smart, hilarious, and even touching while all the time remaining respectful of the audience's ability to relate to difficult circumstances without artificial emotional fishing. It is an excellent film marked by one outstanding performance that deserves the attention received come Award Season.

Mixing cancer and comedy doesn't seem like it should go so well, but 50/50 is a film that makes it work. Joseph Gordon-Levitt stars as Adam, a 27 year old easy going guy who unexpectedly gets diagnosed with cancer. The film details his struggle to beat the disease and all the hardships that come along with having to fight a disease as crippling as cancer at such a young age. Adam is surrounded by various other people in his life that all influence him in different ways. Seth Rogen plays his best friend, Kyle, who always tries to help Adam out, but doesn't always know how to go about it. Anna Kendrick plays Adam's therapist, Katherine, whose attempts to help Adam cope with the cancer work at times, but at other times she just can't find the right way to connect with the grieving youngster. Bryce Dallas Howard plays Adam's girlfriend and Anjelica Houston is one of the strongest characters, Adam's overprotective mother. The film is a compassionate tale of love and friendship while simultaneously being a raunchy pothead comedy. The overlap is strange, but it works incredibly well.

There are so many ways to do a comedy film about cancer wrong, but very few ways to do it right. 50/50 thankfully manages to find the sweetspot of this risky terrain and succeeds in being a charmingly touching film as well as a wildly hilarious one. The writer of the film, Will Reiser, based the film on his own experiences with fighting and beating cancer at a young age, and his passion and understanding of this story shine beautifully through the film and its characters which surely all resemble Reiser's own friends and family in some way. 50/50 doesn't lean too far to either side of the comedy versus drama spectrum and it always maintains a consistent level of heartwarming hilarity balanced with touching sincerity. The drama and comedy weave in and out of each other perfectly and seamlessly with neither genre feeling inappropriate or out of place. It is sincere filmmaking at its finest.

Moreover, 50/50 just does a great job with its balance of genres, but also with the overall story and the great characters within that story. We grow such passionate empathy for Joseph Gordon-Levitt in a way I never thought could be possible. The film draws us into his troubled world so well and we are rooting for him all the way, cheering on his every move and growing more and more attached to him with every passing moment. We also grow to love the supporting cast who, with the exception of one particular character but I won't spoil anything, support Adam through all his hard times. The characters are all so well written and they play their key roles in Adam's life perfectly. 50/50 is a movie structured to where every character serves a major purpose in furthering Adam's development as well as the development of the plot. And so as we watch the relationships between Adam and the people in his life grow and fade we develop a deeper understanding of his character, making 50/50 an incredibly human story.

It's always nice to be so surprised by a film's quality. I expected good things from 50/50 from the first time I saw a trailer, but the movie itself exceeded my expectations. It is what the dramady subgenre is all about. It is a film tailor made to be the subgenre's posterchild. I laughed, I lamented, and I was brought close to tears at how heartwarming and touching of a film 50/50 is.

Greetings again from the darkness. The great Richard Pryor had a portion of his act dedicated to having a heart attack, based on his real life experience. I guess if he can generate laughter from a coronary, there is no reason writer Will Reiser and director Jonathan Levine (The Wackness) can't view Cancer as Comedy. There is little doubt that the subject matter of this film will limit its audience, but for those brave souls who give it a shot, I believe you will find it funny, touching and insightful.

The film introduces us to Adam (Joseph Gordon-Levitt) who is a very nice, very normal, very low-key guy who works at a radio station as a writer ... a very conscientious radio writer. Adam experiences a nagging pain in his back, which is unusual for a healthy 27 year old. After a few tests, the emotionless doctor informs him that he has a rare spinal cancer ... also very unusual for a healthy 27 year old. From this point forward, the film borders on brilliance at times.

Adam's girlfriend is played by Bryce Dallas Howard; his mother by Angelica Huston; and his best friend by Seth Rogen. Each reacts in different ways to Adam's diagnosis, but what's really interesting is not just how these people react, but also how Adam reacts. He moves forward in his meticulous manner, but all the while we know the emotions are brewing. We see this in his sessions with his therapist-in-training played by Anna Kendrick.

Seth Rogen's character is basically a carbon copy of his act in 40 Year Old Virgin. He spews profane one-liners faster than our ears can process. Despite the aggressive front, Rogen's character is a friend with a heart ... and one who doesn't hesitate to share his medicinal marijuana.

So while Rogen's character generates much of the laughter, the real treasure of this film is in the subtleties of each character in certain moments ... and each character has their moment. Many will compare this to Adam Sandler's film Funny People, which also starred Seth Rogen. But this movie has infinitely more depth and substance than that one offered.

My warning: brace yourself. My theatre was filled with tears and sniffles, with significant laugh out loud moments mixed in. This is an emotional, self-reflective film that will confound you as you inexplicably laugh while listening to cancer talk.

As someone who was diagnosed with cancer two years ago (non-small cell lung cancer--and a nonsmoker to boot!) I've been through the gantlet, from 4 different kinds of chemo, several surgeries, and a wide variety of medical care from indifferent to deeply caring. So, trust me when I tell you, that this movie gets it.

It gets what it is like to receive a horrific diagnosis out of the blue, the numbness and shock of dealing with it, the well meaning friends and acquaintances who say the stupidest things ("every time I feel sorry for myself, I just think of you..."), and those friends who really become your rock as you go through the miasma of treatment and try to still make your life have meaning. Again, this movie gets it.

Joseph Gordon Levitt and Seth Rogen deserve high praise for the honesty that they bring to their performances. There was not a false note anywhere. The rest of the cast is terrific as well. I plan to see it again when it is released in a month.

This is a quiet film but it packs a great deal of power. I thought the humor was wonderfully placed, because without humor, life with cancer is unbearable. As too many folks know so well. Go see it and be entertained and learn a bit and rejoice in life even with cancer.