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Aspiring film actress Penny moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.

Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.—Huggo

The lives of two geniuses named Dr. Leonard Hofstader and Dr. Sheldon Cooper change when they meet their new neighbor; motivated but unsuccessful actress Penny, who now works as a waitress at The Cheesecake Factory. As they struggle socially, Penny decides to help them discover the world that they know everything about, but yet know nothing about how to live in it. Friends Howard and Rajesh are along for the ride.—Naw Neine

The Big Bang Theory is a comedy about brilliant physicists, Leonard and Sheldon, who are the kind of "beautiful minds" that understand how the universe works. But none of that genius helps them interact with people, especially women. All this begins to change when a free-spirited beauty named Penny moves in next door. Sheldon, Leonard's roommate, is quite content spending his nights playing Klingon Boggle with their socially dysfunctional friends, fellow Cal Tech Mechanical Engineer Wolowitz and Astrophysicist Koothrappali. However, Leonard sees in Penny a whole new universe of possibilities - including love.—ahmetkozan

Sheldon Cooper is an insensitive, neurotic obsessive-compulsive who imposes his will on everyone around him and everyone indulges him. Leonard and Penny fight in most episodes and she finds a way to make it his fault. Howard , a momma's boy, swaps one domineering woman for a younger version. Rajesh ruins relationships. This pretty much sums up the entire series.