Daniel Craig was injured at least three times during the making of this movie. The most prominent ones included an injury to his face, which required four stitches, another to his shoulder, which required six surgical screws to be inserted in an operation, and his arm in a sling, and then his hand was injured when one of his finger tips was sliced off. He laughed these off, noting they did not delay filming, and joked his finger wound would enable him to have a criminal career (though it had grown back when he made this comment). He also had minor plastic surgery on his face.
Chile's Atacama Desert (where the finale was filmed) is the driest region on Earth, with no record of any measurable rainfall ever having occurred there.
In a later interview, Daniel Craig revealed that the script originally wasn't intended to be as much of a sequel to Casino Royale (2006) as it ended up being. However, because of the writer's strike, they had only the "bare bones" of a script, and Craig and director Marc Forster ended up re-writing a lot of scenes between them, with many decisions being made on the fly, and at the last second. Much of the content that made it such a direct sequel to Casino Royale (2006) was a last-second addition. Also, the title was chosen more or less at random, with Craig saying that most Bond movie titles are "meaningless" anyway, and they hoped it would sound intriguing. The title didn't really connect with the script they had at the time, and the revenge story elements that actually made the title relevant were last-second additions.
Daniel Craig wasn't fond of how production went, saying that thanks to this, he'd never do a movie without a script nailed down again.
According to Mathieu Amalric (Dominic Greene), his character does not have any distinguishing features to make him more formidable, and to represent the hidden villains of society: "He has no scars, no eye that bleeds, no metal jaw. I tried everything to have something to help me. I said to Marc Forster: No nothing? A beard? Can I shave my hair? He said: No, just your face." Amalric also described Greene as "not knowing how to fight, so James Bond would be more surprised. Sometimes anger can be much more dangerous. I'm going to fight like in school."
Guillermo del Toro: The Mexican movie director provided additional voices in this movie. Del Toro is a friend of director Marc Forster.
Alfonso Cuarón: The Mexican movie director as a helicopter pilot, credited for additional voices. Cuarón is a friend of director Marc Forster.
Michael G. Wilson: As a man reading a newspaper, sitting in a green armchair, while Bond handles a metal case over the counter.
Robert Braithwaite: The managing director of Sunseeker International Powerboats (the boats are regularly seen in the James Bond movies of recent years) as a speedboat operator on a Sunseeker power boat carrying Bond.