Griffin stated that the sixth season would include an episode with Ryan Seacrest, one of her popular adversaries, titled "An Uncomfortable Lunch with Ryan Seacrest", but the episode never came to fruition and she claims Seacrest stop returning her calls.
In her book "Official Book Club Selection" Kathy Griffin revealed that during the filming of the second season she was separated from her husband Matt Moline, who would arrive before the crew and leave after filming finished, though the season portrays them as still living together.
On the Gay Pimping' with Jonny McGovern pod-cast, co-host Linda James renamed her intern Alessandra to "Pom-pom" after Kathy Griffin's dog from the show.