CM Punk's WrestleMania debut as one of the gangsters hanging off the side of a car during John Cena's ring entrance.
"The Hitman" Bret Hart did not appear at this WrestleMania despite being one of the Hall of Fame inductees. He was uncomfortable being at this event. His name was mentioned a few times during the Pay Per View, and only footage from WWF Survivor Series (1997) was used during the McMahon vs Michaels 'No Holds Barred' match.
Before Eddie Guerrero's tragic death in November 2005, he was scheduled to have a match with Shawn Michaels at WrestleMania 22.
WrestleMania 22 marked the first WrestleMania not to feature the winner of the Royal Rumble in the final match of the night since WrestleMania XV in 1999.
First WrestleMania that The Big Show was victorious in his match.