At the beginning of filming, Natalie Portman gave Julia Roberts a necklace that said "cunt" in honor of their characters' foul mouths. At the end of filming, Roberts gave Portman a necklace that said "lil' cunt".
There are approximately 510 questions asked between the characters. That works out to around 5 questions per minute of run time.
In the build up to the release of the film, word got out that Natalie Portman had shot fully nude scenes for her role as a stripper. Ultimately cut from the film, it was reported that the nude footage was burned by the director Mike Nichols.
Cate Blanchett was originally signed to play the role of Anna, but due to her second pregnancy she had to drop out of the film. She was later replaced by Julia Roberts.