The first-ever all-Flash animated series made for American broadcast television. Flash is primarily used for web cartoons. However, the show is not the first flash animated television series in general; as that honor went to the 2001 short-lived television series John Callahan's Quads!, which was exclusive to Teletoon and the Special Broadcasting Service. The second flash television series was Max & Ruby, another Canadian animated series.
Candi Milo based the voice of The Flea on an impression of Cheech Marin.
The Spanish voice actors of Rikochet and Buena Girl fell in love during production and later married some time after the show ended.
Mr. Midcarda's name comes from "Mid-Card," meaning average in wrestling.
Co-creator Eddie Mort commented that Harvey Comics, 1960s Hanna-Barbera, Ralph Bakshi, and Ren & Stimpy all influenced his work, including ¡Mucha Lucha!