When giant Mojo Jojo rips open the side of the building he's climbing with the Powerpuff Girls in tow, it shows the interior of the second floor of Cartoon Network Studios with caricatures of the actual employees.
According to the Hollywood Reporter, the principal voice actresses Cathy Cavadini, Tara Strong and Elizabeth Daily went on strike because they felt they weren't being paid enough to do a movie, so Cartoon Network threatened to replace them with more popular voice actresses for the movie as well as for the TV series. Fortunately, a deal was made and Cavadini, Strong and Daily were able to reprise their respective roles as Blossom, Bubbles and Buttercup.
Despite being a major box office bomb during original theatrical release, the film was soon rushed to home video and has managed to gain a cult following ever since among Powerpuff Girls fans.
The newspaper reporting the girls "tag" disaster has a picture of Powerpuff creator and director Craig McCracken in the top corner.