It was generally believed that Jeri Ryan (Seven of Nine from Jornada nas Estrelas: Voyager (1995)) was offered a cameo in the earliest draft of the movie script, but was unable to commit when she got a role on Boston Public (2000). The cameo was supposedly given to Kate Mulgrew (Admiral Kathryn Janeway) instead. However, during a 2014 Star Trek convention, Ryan admitted that the studio had offered her a much larger role, which would have replaced an unspecified character in this film (supposedly Marina Sirtis as Deanna Troi). Ryan passed on the opportunity, not wanting to take a break from Boston Public already, and also out of fear of being typecast. She also felt that her presence in the film was merely fan service, since her character from Voyager never served on the Enterprise, and therefore wouldn't know anyone from the Next Generation crew. The studio then offered her a cameo as a guest at Riker and Troi's wedding in the beginning, which she also passed on because that would make even less sense. A cameo for Admiral Janeway was created instead, and Ryan would finally return to the Star Trek universe in Star Trek: Picard (2020).
The farewell scene in Captain Picard's ready room, near the ending, had to be reshot after Sir Patrick Stewart unintentionally started crying.
Sir Patrick Stewart was paid nearly as much for this film as he made in the entire run of Jornada nas Estrelas: A Nova Geração (1987).
In an interview given years after this film came out, Tom Hardy said that he took the role very seriously, as it was intended to be his big break. Hardy also admitted that he struggled with mental health and drug issues during the shoot, and that the commercial failure of the film, as well as the negative response from long-time fans, hit him hard. It led to his relationship dissolving, him seriously considering to stop acting, turning to alcohol and even contemplating suicide. It was only when he pulled himself together by seeking professional help and starring in Bronson (2008) that he got over this film, and his career has flourished since.
Bryan Singer: Guest appearance by the man who directed Sir Patrick Stewart in X-Men: O Filme (2000), X-Men 2 (2003) and X-Men: Dias de um Futuro Esquecido (2014). He is the crew member who takes Worf's place at the Tactical console.
Whoopi Goldberg: Reprising her role as the Enterprise-D bartender Guinan from Jornada nas Estrelas: A Nova Geração (1987).
Wil Wheaton: Makes a cameo appearance in this film. The last time Wesley Crusher made an appearance was on Jornada nas Estrelas: A Nova Geração (1987) ("Journey's End", season seven, episode 26).