Griswold the Blacksmith, Wirt the peg-legged boy and Deckard Cain are the only characters from the first Diablo to be seen in this game. However the classes from the first game appear as villains; The warrior appears as the Dark Wanderer, the rouge is Blood Raven, and the Summoner appears as a corrupted version of himself.
The rogue mercenaries have the same appearance as the original rogue hero in the first Diablo.
The unique Dirk, 'The Diggler Dirk', is named after Dirk Diggler from Boogie Nights: Prazer Sem Limites (1997).
Several unique items from the game are re-used from the first Diablo, such as Veil of Steel, Harlequin Crest and Arkaine's Valor.
Rebecca Lowman's debut.