The only installment of the Re-Animator series not filmed in the United States. It was entirely shot in Spain.
Jason Barry's character is named Howard Phillips. The movie is based on a story by H.P. Lovecraft, whose full name is Howard Phillips Lovecraft. Also, the last name of Elsa Pataky's character is Olney, which is the last name of the main character (Thomas Olney) in Lovecraft's story "The Strange High House in the Mist."
Only film in the series not to feature Bruce Abbott as Herbert West's assistant Dan Cain.
Though filmed entirely outside of the United States in Spain, the police and S.W.A.T. vehicles that respond to alarms from the prison bear the license plates in use in the U.S. state of Massachusetts at the time of filming. (Massachusetts has outlawed the death penalty for those convicted by the State's Justice System)
The young doctor played by Jason Barry is called Howard Phillips which are the first two names of H. P. Lovecraft, the writer of the story the first movie was based on.