230 Dalmatian puppies and 20 adult Dalmatians were used during filming.
Filmmakers rubbed Jeff Daniels' face with raw hot dogs in order to get the puppies to lick him on cue.
Despite her character's passion for fur coats, Glenn Close insisted her costumes be made from fake fur.
Jeff Daniels (Roger) says that on more than one occasion, he heard an authoritative voice on the dog-strewn set shout "Sit!" and immediately plopped himself into a chair only to be told, "Not you, Jeff."
When Glenn Close appeared on the set as Cruella in full fright wig, make-up, and costume, one of the dogs playing Perdy repeatedly tried to sneak away.