In an interview co-writer William Applegate Jr. states Anna Nicole Smith "was in the worst, drug-addled part of her life" during filming of 'Skyscraper'. "She'd also go missing for an hour and Martino [the director] would go missing for an hour. They'd send a PA off to go look for them and discover him going down on her in the trailer. In the middle of production! It was just ridiculous."
There was an attempt to re-edit the movie while removing any scenes with nudity to be aired on TV.
The film is a spoof of Die Hard (1988), with a lot of plot similarities.
Skyscraper was inspired by Die Hard.
Deron McBee and Director Richard Pepin worked together on T-Force, Out for Blood, Skyscraper and Payback.