When asked to name his favorite thing about making this film, André René Roussimoff replied, without skipping a beat, "Nobody looks at me." He felt he was treated as an equal, without people staring at him because of his size.
Mandy Patinkin has said that the role of Inigo Montoya is his personal favorite over the course of his entire career.
During the filming of some scenes, the weather became markedly cold for Robin Wright. André René Roussimoff helped her by placing one of his hands over her head; his hands were so large that one would entirely cover the top of her head, keeping her warm.
Robin Wright and Cary Elwes were smitten with each other during filming, naturally helping their chemistry in the movie. Elwes said that he "couldn't concentrate on much of anything after that first encounter with Robin."
Director Rob Reiner left the set during Billy Crystal's scenes because he would laugh so hard that he would feel nauseated.