Les Nessman wears a bandage on some part of his body in almost every episode. Eventually, he reveals that he has a very large dog at home. In real life, Richard Sanders was injured before taping Pilot: Part 1 (1978), and had to wear a bandage on the air. He decided to make it Les' trademark.
In some scenes, bulletin boards or wall spaces are plastered with bumper stickers for radio stations across the USA. They were sent by real-life radio DJs who were avid fans of the show.
The character of Bailey Quarters was based on Hugh Wilson's wife. Wilson wrote the character to be shy and soft-spoken, but very articulate when she did speak, because his wife was the same way.
The show was videotaped instead of filmed because the rights to rock songs were cheaper for a taped show than for a filmed show.
The show was famous for playing music of up-and-coming bands. Many artists have said that their music being on the show helped their popularity, including Blondie, U2, The Cars, TOTO, The Knack, and Devo. Blondie was so grateful for the show making their song, "Heart of Glass," a hit that they gave their Gold Record to the producers. It's hanging in the WKRP bullpen in seasons 2 to 4.