The patriarch and matriarch of the Hubbard family, Marcus and Lavinia, are played by real-life husband and wife Fredric March and Florence Eldridge who had previously teamed onscreen in O Crime do Estúdio (1929), Os Implacáveis (1935) and Mary Stuart, Rainha da Escócia (1936), the last-named being Eldridge's most recent screen credit prior to ''Another Part of the Forest''. Subsequently Eldridge and March would re-team in Piedade Homicida (1948) (also starring Edmond O'Brien), Cristóvão Colombo (1949), and - again as married Southerners - O Vento Será Tua Herança (1960), these three films comprising Eldridge's entire cinematic career subsequent to ''Another Part of the Forest''.
Dan Duryea was originally cast as Ben Hubbard: after that role was re-cast with Edmond O'Brien, Duryea (despite being eight years O'Brien's senior) was cast as younger Hubbard brother Oscar, thus playing the father of his Pérfida (1941) character Leo. Forty-year old Duryea's hair was bleached for the film in the belief that fair hair would make him a more believable twenty-five-year old.
In this companion piece to The Little Foxes, Ann Blyth plays Regina, the scheming character who was portrayed by Bette Davis in the "sequel."
"Lux Radio Theater" broadcast a 60 minute radio adaptation of the movie on
September 13, 1948 with Ann Blyth reprising her film role.
In December 1946, Universal Pictures began negotiating for the film rights for Lillian Hellman's Broadway hit ''Another Part of the Forest'', which they from the outset envisioned as a vehicle for contract player Ann Blyth, having won acclaim for her dramatic role on loan-out to Warner Bros. in Alma em Suplício (1945).