The skyline at the beginning of the show is that of Cincinnati, Ohio as seen from Kentucky. Cincinnati is the headquarters of Proctor & Gambel, the show's longtime sponsor.
When Teal Ames' character was killed in a 1961 episode, CBS received so many calls after the episode's broadcast that Ames and John Larkin had to appear at the end of the next day's program to reassure viewers that only Ames' character, not the actress herself had died.
Bebe Neuwirth's television debut.
When he was on the show, Stephen Markle portrayed Ted Loomis, a corrupt cop who eventually became a serial murderer. Loomis killed several other characters, and the fans loved him and wanted him to keep killing even more characters. The producers became alarmed that his evil, psychopathic character was becoming too popular. As a result, it was decided to write out Loomis by killing the character. Fans were shocked and outraged by this decision.
Most of the CBS-era episodes are presumed to be lost, a common problem of older programs recorded on videotape.