The only original actors that are involved in all four Hotel Transylvania films are Selena Gomez, Andy Samberg, Steve Buscemi, David Spade, Fran Drescher and Molly Shannon. Adam Sandler, Kevin James and Sandler's daughter Sadie Sandler were in the first three films before they were replaced by Brian Hull, Brad Abrell and Zoe Berri in this film, and CeeLo Green was in the first film before he was replaced by Keegan-Michael Key in all three sequels.
Steve Carell was considered to replace Adam Sandler as the voice of Dracula before Brian Hull was confirmed.
The first Hotel Transylvania film not to feature Kevin James as Frankenstein. Instead, Frankenstein is voiced by Brad Abrell.
The first Hotel Transylvania film not to feature Adam Sandler as Dracula. Instead, Dracula is voiced by Brian Hull who also voiced the character in Pets Monstruosos: Um Curta do Hotel Transilvânia (2021).