The movie world premiered on February 18, 2021 at the Hollywood Legion Drive-in. Linton's husband, former U.S. Secretary of the Treasury Steve Mnuchin, did not attend. Only 25 cars showed up and half of them left before the movie was over, according to The Hollywood Reporter.
Louise Linton came up with the concept for You Me Madness after falling asleep in a hot car following a trip to the pharmacy. She described a 'Doors-like vision' of an indigenous man telling her to make a movie about a girl-boss serial killer. So she did.
According to Vanity Fair, Linton changes outfits 42 times in the movie in the 98 minute movie.
According to a Daily Mail interview she gave in January 2024, Linton wrote the script for the movie in just two weeks.
The curving glass-and-steel home where the bulk of the film was shot is a common filming location. The Malibu mansion was designed by architect Ed Niles and is set on nearly 17 acres on a private knoll. Other movies shot there are Starship Troopers, Face / Off, Gone in 60 Seconds, Fun with Dick and Jane , The Benchwarmers, and Britney Spears' "Work B**ch" music video.