Tony Anselmo reprises his role of Donald Duck from DuckTales: Os Caçadores de Aventuras (1987); while it was a minor role in that show (he left the nephews with Scrooge when joining the navy, appearing in only a few episodes), it's a bigger role in this show.
According to Matt Youngberg, Huey, Dewey, and Louie have more developed characteristics in this show, whereas in previous shows they were indistinguishable from each other. "Everyone always says Huey, Dewey, and Louie in that exact order, so we decided to make that the birth order, and by defining that we were able to assign traits that fit. Huey's the oldest, a little more responsible, a little bit brainy. Dewey wants to stand out, and wants to break out of being labeled as just one of a set of three. And Louie is happy being the youngest child - he can slip under the radar. Huey has Scrooge's brains, Dewey has Scrooge's guts, and Louie has Scrooge's love of treasure."
In the opening credits, when the Duck family pulls apart the mummy, a hieroglyph of Darkwing Duck can be seen on the wall.
The producers cite the Indiana Jones films and the family comedy Arrested Development (2003) as an influence on the show.
Flintheart Glomgold's characterization in this show is being a cheap knock-off of Scrooge McDuck: "When Glomgold saw that Scrooge was a Scottish billionaire, he decided to be more Scottish and even richer. He's an '80s billionaire who made all his money from branding and getting his face on every storefront."
Furthermore, Keith Ferguson (Glomgold) is American, and David Tennant (Scrooge) really IS from Scotland.
Furthermore, Keith Ferguson (Glomgold) is American, and David Tennant (Scrooge) really IS from Scotland.