- In 2007, she was diagnosed with ovarian cancer. She had tumors on both ovaries and the cancer had spread into her lymph nodes and surrounding tissues. For the next couple of years, she underwent many surgeries to remove the cancerous tissue in her body. She was left with one third of an ovary and was told she would never be able to get pregnant naturally. The doctors were wrong: she went on to welcome two daughters with husband Taran Killam.
- Was voted "Most Respected" by her classmates in her senior year of high school.
- Fluent in French.
- Much like her character Robin Scherbatsky, who received dual citizenship, she became an American citizen in 2020.
- (September 8, 2012) Married her boyfriend of seven years and father of her 3-year-old daughter named Shaelyn, Taran Killam, following a 3-year-long engagement. Her full legal name became Jacoba Francisca Maria Smulders-Killam.
- She has four sisters and three brothers: Melissa, Scott, Amy, Mark, Fiona, Adam and Julie Smulders.
- The finale episode of her show Como Eu Conheci Sua Mãe (2005) was released, and was one of the most watched episodes of the series, the same week that her film Capitão América: O Soldado Invernal (2014) opened at #1 at the US box office.
- Is a certified scuba diver and former model.
- Ranked #9 on Maxim magazine's Hot 100 Women of 2011 list.
- She is exactly two days younger than her husband, Taran Killam.
- While announcing his departure from the long-awaited Mulher-Maravilha (2017) feature, Joss Whedon joked that she was his choice to play Princess Diana of Themiscyra (WW herself).
- She has Dutch (father) and British (mother) ancestry.
- The name "Smulders" is a Dutch name which means "Son of a Miller" (translated and degenerated from older Dutch). Smulders is a typical name from the South of The Netherlands, the Province "Noord-Brabant" , specially in and around the cities Tilburg, Eindhoven and 's-Hertogenbosch.
- Gave birth to her second child, at age 32, daughter Janita Mae Killam in January 2015. Child's father is her husband, Taran Killam.
- Participated in various sports as a teenager including tennis, soccer and swimming.
- Gave birth to her first child at age 27, a daughter named Shaelyn Cado Killam on May 16, 2009. Child's father is her fiancé (now husband), Taran Killam.
- Named one of the "most desirable" famous women for 2013 in Askmen's list of the Top 99 Most Desirable Women.
- Her father is a dentist and her mother worked as an official fundraiser.
- Currently resides in New York City. (janeiro de 2014)
- Born on the same date as Sofia Boutella.
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