- He is known for being able to compose a full film score in a short time.
- Started playing piano at the age of 5.
- In his early teens, he started collecting soundtrack albums. He became acquainted with the music of several composers including Max Steiner, Franz Waxman, Maurice Jarre, and Georges Delerue.
- His Greek mother and French father met in the US while attending university. After the marriage, they moved to France where Desplat was born.
- One of 115 peopled invited to join AMPAS in 2007.
- Was nominated for Film Composer of the Year by the International Film Music Critics Association in 2007, 2008, 2009 and 2011. He only won the award in 2007.
- First met his wife, Dominique LeMonnier, while working on his first film score in 1986.
- He has provided the score for 3 films that have won the Oscar for Best Picture: O Discurso do Rei (2010), Argo (2012), and A Forma da Água (2017).
- As of 2022, he has composed the music of twelve films that were nominated for the Best Picture Oscar: A Rainha (2006), O Curioso Caso de Benjamin Button (2008), A Árvore da Vida (2011), O Discurso do Rei (2010), Tão Forte e Tão Perto (2011), A Hora Mais Escura (2012), Argo (2012), Philomena (2013), O Jogo da Imitação (2014), O Grande Hotel Budapeste (2014), A Forma da Água (2017) and Adoráveis Mulheres (2019). Of those, O Discurso do Rei (2010), Argo (2012) and A Forma da Água (2017) are winners in the category.
- Second winner of the Life Achievement Kilar Award, of FMF Krakow Film Music Festival, named after late composer Wojciech Kilar, in 2016.
- Graduated from Royal College of Music.
- Although he was born on August 23rd, both his Sun and ascendant/rising signs are in Leo.
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