- Quit drinking alcohol after being arrested for drunk driving in March 2008.
- In a 2005 interview, he claimed that O Justiceiro (2004) was both the most fun and the most physically exhausting movie he has done.
- The son of Michael and Cynthia (nee Jane) Elliott, the actor adopted his mother's maiden name, claiming to "like having a woman's first name as a last name".
- Always signs autographs.
- Co-wrote his own comic book miniseries, Bad Planet.
- Gained between 20 to 40 pounds, and then underwent brutal and rigorous work-out sessions to turn that into muscle weight, all for the role of O Justiceiro (2004).
- Was offered a chance to reprise the role of Frank Castle in O Justiceiro: Em Zona de Guerra (2008), but turned it down.
- Like Dolph Lundgren in the earlier O Justiceiro (1989) movie, he dyed his hair jet black to match the original comic book character.
- Former son-in-law of Rutger Hauer.
- Before Jon Hamm was cast, Jane had been sought for the role of Don Draper in Mad Men: Inventando Verdades (2007).
- Was Zack Snyder's first choice for Edward Blake/The Comedian in Watchmen: O Filme (2009), but he had to turn it down because of scheduling conflicts with Dark Country (2009).
- Has starred in three movies based on Stephen King's novels: O Apanhador de Sonhos (2003), O Nevoeiro (2007) and 1922 (2017).
- Engaged in 2002, he wed Patricia Arquette at the Palazzo Contarini in Venice on June 24, 2006. Their daughter, Harlow Olivia Calliope Jane, a.k.a. Harlow Jane, was born on February 20, 2003. Arquette and Jane divorced in 2011.
- Has a close relationship with Steve Niles, a horror comic book writer. His likeness has been used for Niles' supernatural detective, Cal MacDonald, in an attempt to put him in the role for a proposed film.
- Is known to frequently go barefoot, including on set and at cons, expos, and other kinds of public appearances.
- Founded production company Raw Studios along with Steve Niles and Timothy Bradstreet.
- He has said, "I'm part Irish and Scottish, a little German Jew on my mother's side and some Blackfoot Indian on my father's.".
- Was considered for the part of Kainan in Outlander: Guerreiro vs Predador (2008).
- Enjoys playing guitar.
- Was very interested in playing the lead in Jonah Hex - Caçador de Recompensas (2010). He even voiced the character in the animated short DC Showcase: Jonah Hex (2010).
- Of German Jewish, Irish and Scottish descent.
- Is a fan of the alternative band The White Stripes.
- Graduated from Thomas Sprigg Wootton High School in Montgomery County, Maryland.
- Former stepfather of Patricia Arquette's son, Enzo Rossi. Former brother-in-law of Alexis Arquette, Richmond Arquette, David Arquette and Rosanna Arquette. Former son-in-law of Lewis Arquette and Brenda Denaut. Former grandson-in-law of Cliff Arquette and Julie Harrison.
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