- Is the first actor to portray Dr. Hannibal Lecter on the screen.
- Based his portrayal of Dr. Hannibal Lecter on Scottish serial killer Peter Manuel.
- He was awarded the CBE (Commander of the Order of the British Empire) in the 2003 Queen's New Year's Honours List for his services to drama.
- Has no fewer than three roles in common with Anthony Hopkins. They have both played Titus Andronicus, and both of them played King Lear while the other was simultaneously playing Hannibal Lecter.
- Has replaced Tommy Lee Jones in two consecutive 1996 releases: Reação em Cadeia (1996) and Glimmer Man: O Homem das Sombras (1996).
- Backed out of his contract after filming the second of the BBC/Celtic Sharpe series of films after complaining of poor working conditions in the Ukraine as well as becoming repeatedly sick because of them. He was replaced by Michael Byrne, who was featured in the next three Sharpe films.
- As of 2020, Cox lives in New York City, New York, USA, as well as in London, England, UK.
- Although Cox has been vocal about his support for Scottish independence, he did not qualify to have a vote in the 2014 referendum due to his status as a resident of the United States.
- Has appeared in two films about legendary Scottish heroes: Coração Valente (1995) and Rob Roy: A Saga de uma Paixão (1995).
- Is only 7 1/2 years older than Dennis Quaid who played his character's son in Desafio do Destino (2002).
- He was awarded the Laurence Olivier Theatre Award in 1985 (1984 season) for Best Actor in a New Play for "Rat in the Skull".
- His father was of Irish ancestry, while his mother was of Irish and Scottish ancestry.
- Has performed in several movies playing a government official in which another actor has amnesia but later discovers they are secret government assassins: Despertar de um Pesadelo (1996) where the amnesia victim is actress Geena Davis, A Identidade Bourne (2002) with Matt Damon having the amnesia, and also X-Men 2 (2003) where the victim is played by Hugh Jackman.
- Father of actor Alan Cox, who starred in O Enigma da Pirâmide (1985).
- Was elected Rector of Dundee University (Scotland), the city of his birth, and took up the position in spring 2010.
- He was a lifelong supporter of the Labour Party but has since 2015 switched to supporting the Scottish National Party.
- Rarely plays characters who are sympathetic or likable, from his egotistical take on Robert McKee in Adaptação (2002) to the robust evil in his portrayal of Agamemnon in Troia (2004). However, he has gone against type and played several likable characters, such as the gruff yet honorable Uncle Argyle in Coração Valente (1995) and the lovable, paternal Police Chief John O'Hagan in Super Tiras (2001).
- His father, Charles McArdle Campbell Cox, died when he was age 9.
- Is the youngest of five children.
- He was awarded the 1987 London Critics Circle Theatre Award (Drama Theatre Award) for Best Actor for his performances in "The Taming of the Shrew", "Titus Andronicus" and "Fashion".
- Alumnus of the London Academy of Music and Dramatic Art.
- Has won two prestigious Laurence Olivier Best Actor Awards for performances on London's West End stage - "Rat in the Skull" and William Shakespeare's "Titus Andronicus".
- Although it is indicated in X-Men 2 (2003) that his character (William Stryker) is at least 20 years older than Bruce Davison's character (Senator Robert Kelly), in real life, he is only 27 days older.
- After graduating from LAMDA, he spent several seasons with the Royal National Theatre in London, England.
- [2009] Owns two Toyota Prius cars - one for use at his American residence and one for his British home.
- Member of the Royal Shakespeare Company (RSC) in Stratford Upon Avon, England, where he is most recognized for his 1987 performance as Titus Andronicus.
- Currently (2020) doing voiceover/narration for McDonald's (fast food restaurant) commercials.
- Has appeared in Caçador de Assassinos (1986) with Joan Allen, they went on to work together 18 years later on the movie A Supremacia Bourne (2004).
- Caçador de Assassinos (1986) was remade as Dragão Vermelho (2002), the original title of the novel on which it is based. Cox has appeared in films with several actors from the remake. He appeared with Edward Norton and Philip Seymour Hoffman in A Última Noite (2002), with Emily Watson in O Lutador (1997) and Meu Monstro de Estimação (2007), Mary-Louise Parker and Anthony Hopkins in RED: Aposentados e Perigosos (2010) and RED 2: Aposentados e Ainda Mais Perigosos (2013), and Ralph Fiennes in Coriolano (2011). Frankie Faison appeared in both films.
- Began his acting career at the Dundee Repertory Theatre.
- Has played Hannibal Lecter in the mystery thriller Caçador de Assassinos (1986). In 2002, he co-starred with Edward Norton and Philip Seymour Hoffman in the film A Última Noite (2002). In 2002, Norton and Hoffman also starred in Dragão Vermelho (2002), which was a remake of Caçador de Assassinos (1986).
- He was awarded the Laurence Olivier Theatre Award in 1989 (1988 season) for Best Actor in a Revival for William Shakespeare "Titus Andronicus".
- He was awarded the 1984 London Critics Circle Theatre Award (Drama Theatre Award) for Best Actor for his performances in "Rat in the Skull" and "Strange Interlude".
- In 1995, he appeared in two films revolving historical Scottish figures who fought with British forces: Rob Roy: A Saga de uma Paixão (1995) and Coração Valente (1995).
- He has appeared in three films that have been nominated for the Best Picture Oscar: Nicholas e Alexandra (1971), Coração Valente (1995) and Ela (2013). Braveheart won in the category.
- Has four children: Alan Cox (a professional actor) and Margaret Cox, from his 18-year marriage to Caroline Burt (they divorced in 1986). His second son was born January 31, 2002 and his third son Torin Kamran Charles Cox was born October 2004 from his wife Nicole Ansari-Cox.
- When Game of Thrones (2011) was in its early stages of development, Cox declined an offer to play Robert Baratheon because the monetary rewards were then relatively scant. However, as he watched the series gradually gain immense global popularity, he began to rue his short-sighted decision.
- The scene in X-Men 2 (2003) where Magneto escapes from prison is modeled after Hannibal Lecter's escape in O Silêncio dos Inocentes (1991) - the sequel to Cox's film Caçador de Assassinos (1986), in which he played Lecter.
- Has appeared with Joan Allen in Caçador de Assassinos (1986). Each of them later went on to work with the other's successor. Cox's successor as Lecter, Anthony Hopkins, appeared in Nixon (1995) with Allen. Cox worked with Allen's successor, Emily Watson, in O Lutador (1997).
- Among the actors thought suitable for the role of Roger Derebridge in the science fiction horror film Força Sinistra (1985). The role eventually went to Nicholas Ball.
- Was engaged to actress/theatre director Irina Brook.
- He has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Três é Demais (1998).
- His second son, Torin Kamran Charles Cox, was born October 2004.
- Was not only the first of three actors to play Hannibal Lecter, he was also the first of them to appear in a film based on a Marvel comic book, each of which would make reference to Lecter. Magneto's escape in X-Men 2 (2003) was modeled after Lecter's escape in O Silêncio dos Inocentes (1991). Anthony Hopkins plays the father of Loki in Thor (2011) and its sequels; Loki himself played a scene opposite Black Widow in which he is trapped behind glass, not unlike Lecter and Clarice Starling. They are also discussing Bruce Banner, a character previously played by Edward Norton. Mads Mikkelsen wears a face mask resembling Lecter's in Doutor Estranho (2016).
- Has worked with two Eomers. In the Sharpe films (Sharpe's Eagle (1993) and Sharpe's Rifles (1993)), with Sean Bean, he appears with Anthony Hyde, who played the role in the BBC radio broadcast. In A Supremacia Bourne (2004), he appears with Karl Urban, who played the role in Peter Jackson's films.
- He played William Wallace in The Wallace (1975) and William Wallace's father, Argyle Wallace in Coração Valente (1995).
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