- Joseph was originally going to play Jack Banning, Robin Williams' son in Hook: A Volta do Capitão Gancho (1991), but he was too young for the part. Steven Spielberg went out of his way to the point of changing the script for Jurassic Park: O Parque dos Dinossauros (1993) so that Joseph could play Tim.
- In the original 1990 novel of Jurassic Park, Tim was age 11 and Lex was age 8. Steven Spielberg swapped their ages in Jurassic Park: O Parque dos Dinossauros (1993) so that Joseph could play Tim.
- Favorite actor is his idol, James Stewart.
- Has been passionate about oldies music, and when he was growing up, his sister teased him for being old-fashioned.
- Favorite movie is A Felicidade Não se Compra (1946).
- Radio Flyer (1992) began filming on Joe's 7th birthday.
- Brother of John Mazzello, also has an older sister, Mary.
- When work began on A.I.: Inteligência Artificial (2001) in 1993, he was cast as David. That film would end up being directed by his Jurassic Park: O Parque dos Dinossauros (1993) director, Steven Spielberg. His encounter with the velociraptors in that film was itself a reference to Stanley Kubrick's film O Iluminado (1980).
- His parents own and operate a dance studio
- He played Richard Attenborough's grandson in Jurassic Park: O Parque dos Dinossauros (1993). Attenborough later cast him as Douglas Gresham in Terra das Sombras (1993), his next film as a director.
- Graduated from USC with a degree in cinema-television (2005)
- Attended Our Lady of Lourdes High School in Poughkeepsie, NY.
- Was put under a contract in 1993 for Wartime Lies, a screenplay based on the novel by Louis Begley, under direction of the late Stanley Kubrick. He was on the contract for two years. The movie was never made. It did however, lead to rumors of him being in A.I.: Inteligência Artificial (2001).
- Was considered one of the 55 faces of the future by Nylon Magazine's Young Hollywood Issue.
- His father is of three quarters Italian, and one quarter German Jewish, descent. His mother is of Irish, and small amounts of English and Dutch, ancestry.
- A student at the University of Southern California (USC), as a Cinema-Television major [May 2002].
- Raised in Hyde Park, New York.
- Plays John Deacon in Bohemian Rhapsody (2018) and has a dog named Deacon in O Pacífico (2010).
- He has appeared in two films that have been nominated for the Best Picture Oscar: A Rede Social (2010) and Bohemian Rhapsody (2018).
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Jurassic Park: O Parque dos Dinossauros (1993) and A Rede Social (2010).
- His hometown of Hyde Park, NY is where Franklin D. Roosevelt used to live.
- Born on the same date as Maggie Grace.
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