- She took the stage name Ledoyen, which is her paternal grandmother's maiden name. Her grandmother had been a French stage actress. Her paternal grandfather was of Spanish descent.
- Has 3 children: a daughter Lilias Soubrier (b.Septemebr 29, 2001) with her ex-boyfriend Louis Soubrier; a son Isaac Elmaleh (b.July 2010) and a daughter Amalia Elmaleh (b.April 23, 2014) with her ex-boyfriend Arié Elmaleh.
- Was a model in print and on TV from the age of 2.
- L'Oreal celebrity model (2000-2005).
- Favourite actresses are Sophie Marceau and Isabelle Huppert.
- Her first on-screen kiss was with the much older actor Marcello Mastroianni.
- Was in a relationship with Arié Elmaleh from 2007 to 2015. They have 2 children together.
- Nominated for Most Promising Young Actress at the 1996 César Awards for her role in Benoît Jacquot's Uma Garota Solitária (1995). Also nominated for Best Actress at the Paris Film Festival for the film Jeanne et le garçon formidable (1998).
- Hosted the Cannes Festival's awards presentation. (26 de maio de 2002)
- Graduated from Paris' L'Ecole des Enfants du Spectacle.
- Met ex-companion Louis Soubrier while they both were working on the set of Uma Garota Solitária (1995).
- Sang with Pascal Obispo for the song "Qu'on me parle plus de toi" on the album Ensemble.
- Has supported Lionel Jospin's 2002 presidential campaign.
- Her brother, Michael, was a production assistant.
- Member of the jury at the Venice Film Festival in 2013.
- Is an avid singer.
- Was romantically linked to Benjamin Biolay and Pascal Laugier.
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