- His college roommate and best friend was the brother of his future co-star on West Wing: Nos Bastidores do Poder (1999), Richard Schiff.
- Is close friends with Studio 60 on the Sunset Strip (2006) co-star Matthew Perry.
- He and his ex-wife, Jane Kaczmarek, have three children: Frances Whitford was born in January 1997; George Whitford was born on December 23, 1999 and Mary Louisa Whitford was born on November 25, 2002.
- Played a Republican Chief of Staff in Meus Queridos Presidentes (1996) and a Democratic Deputy Chief of Staff in West Wing: Nos Bastidores do Poder (1999).
- Founded the charity "Clothes off our Back" (http://www.clothesoffourback.org) with his wife, Jane Kaczmarek, in 2002. Clothes off our Back run on-line auctions after major awards shows where celebrities' gowns and tuxedos, and other articles of clothing, are auctioned off. The proceeds go to children's charities such as Cure Autism Now (http://www.cureautismnow.org) and The Children's Defense Fund (http://www.childrensdefense.org/)
- Graduated Wesleyan University (Middletown, Connecticut), 1981. Attended Juilliard.
- If he could change one thing about his life, he would have started dancing when he was young.
- Gave the commencement speech at the University of Wisconsin-Madison in May 2004. His wife is a distinguished alumna of UW-Madison.
- Was in O Cliente (1994) with Mary-Louise Parker, who later played his love interest on West Wing: Nos Bastidores do Poder (1999).
- Traveling around Ohio and Wisconsin as a political surrogate for President Barack Obama, Senator Sherrod Brown (D-Ohio), US Senate candidate Congresswoman Tammy Baldwin (D-Wisconsin), and others. (outubro de 2012)
- Graduated high school on June 4, 1977, from Madison East High School in Madison, Wisconsin.
- As of 2018, has appeared in four films that were nominated for the Best Picture Oscar: Tempo de Despertar (1990), Perfume de Mulher (1992), Corra! (2017) and The Post: A Guerra Secreta (2017).
- Waited tables at "Panarellas" at 84th & Columbus, New York City.
- He is of English, German, Scottish, Irish, and Dutch descent. Many of his family lines trace back to New England (Massachusetts, Connecticut, Vermont) of the 1600s.
- California - Participating in a video in favor of CA Ballot Proposition 30, a CA Constitutional Amendment to temporarily increase income and sales taxes for education and public safety funding. (setembro de 2012)
- Despite Billy Madison (1995) being one of the most famous films he has acted in, he actually never saw the Final Cut of the film after it was released.
- Son of George Van Norman Whitford and Genevieve Smith Whitford, a poet and writer.
- Starring as "Detective Dan Stark" in the television series The Good Guys (2010). (maio de 2010)
- Starring in "Boeing Boeing" on Broadway. (junho de 2008)
- Actor Daniel von Bargen has coincidentally appeared with husband and wife actors Jane Kaczmarek and Bradley Whitford in four different projects. Along with Kaczmarek, he appeared in Malcolm (2000). With Whitford, he was in RoboCop 3 (1993), Filadélfia (1993) and West Wing: Nos Bastidores do Poder (1999).
- Working on Studio 60 on the Sunset Strip (2006), a new show set to premiere on NBC in the fall. (junho de 2006)
- Born on exactly the same date as Julia Sweeney of "SNL" fame.
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