- Has a long history with Star Trek, having appeared on three television series and one film, as two Klingons, a Dosi, a Jem'Hadar and a Romulan.
- He was hired for his role on Jornada nas Estrelas: A Nova Geração (1987) (episode "A Matter of Honor"), and then dismissed without notice before this was filmed. When he sought out a reason why, he was told that he was too large to fit into the costume Christopher Lloyd wore in Jornada nas Estrelas III: À Procura de Spock (1984). He quickly volunteered to make any necessary alterations himself.
- Windsurfs and kitesurfs to stay in shape. Hit two holes-in-one in the same year on the same golf course, same hole. Has a black belt in Hapkido.
- Received his Master's degree in Fine Arts for theatre (acting) from the University of California, Irvine.
- Has played recurring characters on several television series. But on Jornada nas Estrelas: Deep Space Nine (1993), Buffy: A Caça-Vampiros (1997) and Charmed: Jovens Bruxas (1998), he played different characters in different episodes. He also played two different aliens in the film Missão Alien (1988) and the television series Missão Alien (1989).
- Is the Director of the Actor's School of Mount Hood Community College in Portland, Oregon.
- Is the only actor to appear in both the film Missão Alien (1988) and the subsequent television series Missão Alien (1989).
- Received his Bachelor's degree in business management and engineering from Central Washington University in Ellensburg, Washington.
- Has played shapeshifting characters at least five times: Arquivo X (1993), Aves de Rapina (2002), O Lobisomem Ataca de Novo (1987), Buffy: A Caça-Vampiros (1997) and A Hora do Espanto 2 (1988).
- Currently resides with his family in Kelso, Washington.
- When not playing aliens, Brian has taken on a quirky series of human characters. He has been a Scandinavian wrestler on an episode of Weird Science (1994), a prisoner on the premiere episode of Hércules: A Lendária Jornada (1995), and a brawling redneck on Chuck Norris: O Homem da Lei (1993).
- Raised on the Columbia River in Longview, he learned the value of academics and athletics, as the son of two teachers and the second of six siblings.
- Has won critical praise for his character Sheriff Cody Jeremiah Jefferson on the Fox comedy-drama series Key West (1993).
- Cast against his "bad-guy" type, Thompson stars in a family film, The Tillamook Treasure (2006) as Uncle Jimmy, a rough around the edges Oregon logger.
- Has appeared with Jeffrey Combs in three different productions: Doctor Mordrid: O Mestre do Desconhecido (1992), Jornada nas Estrelas: Deep Space Nine (1993) and Jornada nas Estrelas: Enterprise (2001).
- Has two children with Isabelle Mastorakis: Jordan Reese Thompson (born 1988) and Daphne Avalon (born 1990).
- Once portrayed a villain on the television series Hércules: A Lendária Jornada (1995). He played the divine hero Hercules in the miniseries A Vingança do Gladiador (2000).
- Has played the first character killed by the title character in O Exterminador do Futuro (1984) (Unless you count Bill Paxton).
- Is one of several actors to play two different villains on the television series Buffy: A Caça-Vampiros (1997). Tom Lenk, Jeff Kober and Camden Toy were others.
- Attended and graduated from Mark Morris High School in Longview, Washington, where he was on the swimming and football teams.
- Rather like playing comedy.
- Has appeared in two sci-fi thriller films that concern nuclear war: O Exterminador do Futuro (1984) and Miracle Mile (1988).
- Has gathered some bad reputation for his portrayal of Shao Khan in the unpopular video-game movie-sequel Mortal Kombat: A Aniquilação (1997).
- Former son-in-law of Nico Mastorakis.
- Has the Guinness world record for the worlds widest tongue.
- Alan Dean Foster dedicated the novelization of O Exterminador do Futuro: A Salvação (2009) to a Brian Thomsen, no relation to Thompson who played a punk in O Exterminador do Futuro (1984).
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