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Tough female doctors treat an exclusively female clientele at the Rittenhouse Women's Clinic, tackling female-centric issues and trying to make the world a better place in a male-dominated society.

A woman dying of lung cancer claims to be Lu's long-lost sister; Andy suspects a 4-year-old girl is a victim of shaken baby syndrome.

Andy meets the teenage boy responsible for Milo's death; Lu becomes suspicious when an organ-transplant patient suffers from mysterious complications.

Dana treats a promising young figure skater with osteoporosis who is determined to compete in the Olympics; Lu is not thrilled with the father of Marc's new girlfriend.

After kicking her husband out of the house, Andy contemplates whether or not she should tell her daughters about his abusive behavior.

Dr. Andy Campbell joins the Rittenhouse Women's Health Center as Lu's new partner; on Andy's unofficial first day, she clashes with Lu over a woman who had an illegal kidney transplant and a patient of Lu's who refuses to get her young son vaccinated.

Dr. Jackson finds himself in hot water after denying a job to a overweight woman; Dana treats a patient who is diagnosed with Gulf War Syndrome; Lana cares for an abandoned newborn baby.

Lu fears that her unborn child might have a fatal genetic condition and defends a pregnant mother who is accused of welfare fraud.

The parents of conjoined twin daughters refuse to have them separated; Lu suspects that a woman diagnosed with leukemia intentionally started a fire.

Lu, Peter, and Lana host a dance-a-thon and a free mammogram clinic for Breast Cancer Awareness weekend; Lu tries to intervene to help a patient keep her breast and her job after her mammogram reveals a lump; Dana gets some unexpected results of her breast cancer clinical trial and learns that her mother has breast cancer.

Dr. Stowe's mother struggles with her diagnosis with Dana's helping hand. Lu offers to help with her schedule with some amusing results.

Kayla loses a patient who was a bank robber, only for his unstable girlfriend Jamie to show up at the hospital with a bomb strapped to her body. Meanwhile, 35-week pregnant Sirena Adkins is brought in suffering from meningitis and her mom tells Lu to only save the daughter and not the baby.

Andy fights for the rights to an organ from a liver transplant; Lu helps out a woman whose husband has just been released from prison; Nick treats a paramedic who was stuck with a needle from a drug addict.

Lu treats a young college woman with meningitis; meanwhile, Dana develops symptoms which suggest that she might be pregnant.

Lu discovers that two teenage girls have been poisoned by a girl at their high school they have bullied; a patient of Andy asks her to endorse her new heart-health diet book only to end up in the emergency room suffering from a heart attack.

Dana tries to figure out how a virginal young woman got pregnant; Lu cares for a hospital employee who is diagnosed with Lou Gehrig's disease.

Andy diagnoses a woman with West Nile virus; Lu tries to help out a woman and her hospital-bound son.

Lu helps out a woman with carpal tunnel syndrome whose job won't cover her medical condition; Dana treats a pregnant woman and her teenage son for lead poisoning.

A patient of Andy's seeks help to stop her chronic blushing; Lu is unsure about whether or not she should prescribe a painkiller to a recovering drug addict.

Lu treats a female acquaintance of Marc's who is discovered to be pregnant and claims that Marc is the father; Andy becomes a health food advocate at Lizzie's school; Kayla asks Peter to pose as her fiance when her ex-boyfriend comes to town.

Lu discovers that one of Marc's friends is an alcoholic; a patient of Dana's who has Parkinson's wants to undergo an experimental procedure involving aborted fetal cells.

Lu suspects that a young girl's asthma is caused by the stress of her bickering parents; Andy suspects her nanny of theft which turns out to be orchestrated by her daughter Lizzie who was trying to get her parents back together.

Lu helps out a teenage girl who wants to get out of the gang life; Dylan fights to get a young woman with Down Syndrome a heart transplant.

Andy and Milo are invited to stay in a beach-side cabin owned by a patient of Andy's at Cape June, a beach-side vacation community. The vacation gets interrupted when a young boy suddenly becomes very ill with similar symptoms to Andy's patient who has cancer. Andy is further shocked to learn that 9 other residents of the town have died from cancer.

Kayla competes with a fellow male colleague to get the job of chief resident; Lu deals with a teenaged patient who wants to be emancipated so she doesn't have to donate a kidney to her sister.