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- Um médico antisocial faz o que seja para resolver os casos mas difíceis que se encontra com a ajuda do equipe de médicos.
- Shaun Murphy, um jovem cirurgião com autismo e síndrome de Savant, é recrutado na unidade cirúrgica de um hospital de prestígio.
- Histórias de pessoas comuns que se envolvem em situações extraordinárias, nas quais uma curva errada leva à outra, até que seja demais tarde para voltar atrás.
- Dois detetives com visões diferentes do mundo se unem e, usando cinismo, dolo e engano, limpam as ruas de Battle Creek.
- At the turn of the 20th century the Metropolitan Police were overwhelmed with bizarre cases so they turned to outsiders including Houdini and Doyle, who collaborated with New Scotland Yard on some unsolved and inexplicable crimes.
- In a traditionally male-dominated world, one female police officer (Janssen) finds her place at the center of this new drama.
- House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- A very brave and mature 9-year-old girl has terminal cancer, but that is not what the problem seems to be.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- Can House save a high powered female executive from the same problem that has left him in constant pain? A new head of the hospital board could cause problems. Clinic cases: A boy and his mute dad.
- A young boy's fever lasts nearly a week after a Ouija board predicts he will die. Clinic Cases: Chase's case of a man with numb fingers.
- A famous jazz trumpeter, diagnosed with ALS, signs a DNR form, but because House believes the diagnosis wrong, he breaks the law by resuscitating him.
- The team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- Uma freira que sofre de dermatite aguda e asma tratada por House, possivelmente com a medicação errada, chega perigosamente perto da morte.
- A woman collapses at an off-track betting parlor in front of House, and he must battle his new boss to find her diagnosis.
- A girl crashes a Porsche after her boyfriend starts coughing up blood and continues to have unexplained bleeds. Clinic Cases: Cuddy gives House a month off clinic duties if he can spend a week off his pain meds.
- When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- Uma mulher apresenta sintomas da doença do sono africana, mas parece não haver nenhuma maneira de ela ter contraído a doença. House e seus assessores devem fazer algumas perguntas e tomar algumas decisões difíceis para tentar salvá-la.
- A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
- A delusional homeless woman is found unconscious in an acid house exhibiting a variety of symptoms which Foreman thinks she's faking.
- Cuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."
- After being accused of assaulting a sick man, House is forced to take on his case. However, despite the fact that he has AIDS, it's clearly not what's killing him.