- Arrived at her debutante ball on a Harley.
- Sylvia Jefferies's father, James Denis Jefferies, was Mayor of Greenwood, South Carolina; her great-uncle, Richard Manning Jefferies, was Governor of South Carolina. Her mother, Polly, who was one of fourteen children, was an emergency room nurse who began doing international medical mission trips when she was 70yrs old. Her maternal grandfather, Walter Webster, bred horses for harness racing.
- Had a pole installed in her house to learn how to pole dance for a role on Les frères Scott (2003).
- Married her husband in a surprise elopement at O-Ku sushi restaurant in Charleston, SC.
- Has said her favorite actress is Katharine Hepburn.
- Starred in an "E.P.T." commercial, that was parodied by Saturday Night Live (1975) [May 2003].
- Auditioned for the role of "Alex Garrett", on Joey (2004), which went to Andrea Anders.
- Shares a birthday with comedian Steve Martin.
- Studied acting at AADA in New York City.
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