Trivia

Her family are close friends with Helen Mirren, who was a big influence on Sienna when she had an ambition to be an actress.

Good friends with Sarah Michelle Gellar.

Was 3 months pregnant with her twins Valentina and Lucia when she completed filming on her guest stint on Les Experts (2000).

Gave birth to her twin daughters Valentina and Lucia Cilenti, with husband Enzo Cilenti, named after her grandmother and great aunt who are also twin sisters (February 2011).

Was offered the chance to reprise her role as Jill Valentine in Resident Evil: Extinction (2007), but had to turn it down due to scheduling conflicts with Eragon (2006) and the character was then written out of the sequel.

Sienna Guillory is the daughter of the Cuban-born guitarist Isaac Guillory, who is noted for his work with Donovan, Joan Baez, Elkie Brooks, and Mick Jagger.

Is fluent in English and Spanish.

When she age 10, her family moved to Mexico to live with her cousins.

Returned to work 5 months after giving birth to her twins Valentina and Lucia to begin filming The Wicked Within (2015).

Ranked #89 in Maxim's "100 Sexiest Women" (2002).

Split from Brit actor Nick Moran after 4 years together (2000).