- On September 13, 2010, Cuoco was in a horse-riding accident and suffered a very bad break in her leg. She came out of the saddle, landing on the ground, then her horse stepped on the leg, causing so much damage that at first emergency doctors thought amputation of the foot might be required. She was written out of two episodes of The Big Bang Theory (2007) and, for several episodes, was only seen sitting down or behind furniture in an attempt to hide the injury from the audience. Also, in her first appearance following the accident, she was filmed only from waist up, standing behind a bar counter acting as a bartender instead of her usual waitress position..
- Was home schooled on the set and earned her high school diploma at age 16.
- Was in a two-year relationship with Johnny Galecki, like their characters when they were co-stars on the popular sitcom The Big Bang Theory (2007).
- Was a nationally ranked amateur tennis player until she switched to acting full time in 2002.
- Has had the same support team (agents, managers, attorneys and publicists) since she was 15 years old.
- She did six Barbie commercials when she was younger.
- She enjoys horseback riding, kickboxing, bowling, and playing the drums.
- Although she is six years younger than Touche pas à mes filles (2002) co-star Amy Davidson, she played the older sister in the series and they remain best friends.
- Remains close with the cast of Touche pas à mes filles (2002).
- Her last name, Cuoco, translates to "cook" in Italian. Her father is of Italian descent, and her mother has English and German ancestry. Coincidentally, the surname of her now divorced second husband is Cook.
- She was awarded a Star on the Hollywood Walk of Fame for Television at 6621 Hollywood Boulevard in Hollywood, California, on October 29, 2014.
- On June 30, 2018, she married her boyfriend of two years, Karl Cook, in an intimate wedding at a horse stable near San Diego, California, which was attended by close friends and family. They had been a couple since spring 2016, making their first public appearance as a couple in September of the same year. The pair announced that they were engaged on her birthday in November 2017. This was the actress's second marriage.
- Founded Yes, Norman Productions, which is named after one of her rescue dogs.
- First and so far only cast member of The Big Bang Theory (2007) to be nominated for, and subsequently win, a Razzie Award. She won the Worst Supporting Actress trophy in 2016 for her roles in Alvin et les Chipmunks : À fond la caisse (2015) and Témoin à louer (2015).
- Her father, a former paramedic, is now an Oxnard, California, realtor and her mother is a homemaker.
- Friends with actress Cameron Richardson, Charmed (1998) co-star Alyssa Milano, Ashley Tisdale and Brittany Snow.
- Ranked #13 on Maxim magazine's Hot 100 Women of 2011 list.
- The episode of The Big Bang Theory (2007) season 7, episode 14, titled "The Convention Conundrum," is the first episode in which Cuoco's name appears in the opening credits as Kaley Cuoco-Sweeting, following her marriage to Ryan Sweeting. Her revised name appears while the character of her onscreen boyfriend Leonard, played by her IRL ex-boyfriend Johnny Galecki, was seen using his laptop attempting to purchase tickets to Comic Con.
- On August 11, 2024, Cuoco announced her engagement to Tom Pelphrey.
- She loves listening to Josh Groban and Kelly Clarkson.
- Told the media on August 14, 2024, that she is engaged to Tom Pelphrey, father of her daughter Matilda Carmine Richie Pelphrey.
- Was engaged to addiction specialist Josh Resnik [October 25, 2011 - March 2012].
- Ranked #57 in the 2011 FHM Australia list of 100 Sexiest Women in the World.
- Kaley was born November 30, 1985. Her younger sister, Briana Cuoco, was born November 29, 1988, one day before Kaley's third birthday. If 1988 hadn't been a leap year, Briana would have been born on Kaley's birthday.
- Ranked #20 on Maxim magazine's Hot 100 Women of 2014 list.
- Is a huge fan of Britney Spears and Taylor Swift.
- Ranked #78 in FHM magazine's "100 Sexiest Women in the World 2005" special supplement.
- In her role as Penny on The Big Bang Theory (2007), she called everyone "Sweetie"; in 2013, her married name was Sweeting.
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