28 wins & 48 nominations
- 2000 Nominee American Comedy Award
- Funniest Male Performer in a TV Special (Leading or Supporting) Network, Cable or Syndication
- 1997 Winner CableACE
- Guest Actor in a Dramatic Special or Series
- 2003 Nominee Primetime Emmy
- Outstanding Supporting Actor in a Comedy Series
For playing: "Niles Crane". - 2002 Nominee Primetime Emmy
- Outstanding Supporting Actor in a Comedy Series
For playing: "Niles Crane". - 2001 Nominee Primetime Emmy
- Outstanding Supporting Actor in a Comedy Series
For playing: "Niles Crane". - 2000 Nominee Primetime Emmy
- Outstanding Supporting Actor in a Comedy Series
For playing: "Niles Crane".
- 2001 Nominee Golden Globe
- Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 1998 Nominee Golden Globe
- Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 1997 Nominee Golden Globe
- Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 1996 Nominee Golden Globe
- Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 1995 Nominee Golden Globe
- Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 2004 Nominee Golden Satellite Award
- Best Actor in a Supporting Role in a Series, Comedy or Musical
- 2003 Nominee Golden Satellite Award
- Best Actor in a Supporting Role in a Series, Comedy or Musical
- 2000 Nominee Golden Satellite Award
- Best Performance by an Actor in a Series, Comedy or Musical
- 2000 Nominee OFTA Television Award
- Best Host or Performer of a Variety, Musical, or Comedy Special
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