- Has the distinction of being the only actor killed on screen by all three of the Planet Hollywood founders: Bruce Willis (in 58 Minutes pour vivre (1990)), Sylvester Stallone (in Copland (1997)), and most famously by Arnold Schwarzenegger (in Terminator 2 : Le Jugement dernier (1991)).
- Has played the same character (T-1000) in three movies: Terminator 2 : Le Jugement dernier (1991), Wayne's World (1992) and Last Action Hero (1993).
- Immediately after being cast in Terminator 2 : Le Jugement dernier (1991), he took a martial-arts crash course, then began exhaustive strength, endurance, and weapons-training sessions. "For three months," he says, "all I did was sleep, eat, take vitamins, and train.".
- His first ten years in the film business consisted mostly of small parts in "B" pictures; he made so little money from acting that he had to take a job as a bartender to supplement his income.
- Is the older brother of successful musician Richard Patrick, the frontman for the rock band Filter and guitarist for the rock band Nine Inch Nails.
- The appearance of character Dale Gribble from the animated series Les rois du Texas (1997) is based on Patrick.
- Has played the fathers of both Elvis Presley and Johnny Cash: Vernon Presley in Elvis (2005) and Ray Cash in Walk the Line (2005).
- Member of the Boozefighters Motorcycle Club.
- Attended and graduated from Farmington High School in Farmington, Michigan (1977).
- Has appeared in Meat Loaf's music video "Objects in the Rear View Mirror May Appear Closer than They Are" (1994).
- Has reprised his Terminator 2 : Le Jugement dernier (1991) character, the T-1000, for the theme park attraction T2 3-D: Battle Across Time (1996), a short film filmed in a new 3-D process that makes the film really appear to jump out at you.
- Attended Bowling Green State University in Bowling Green, Ohio; majored in accounting.
- Harley-Davidson enthusiast and co-owner of Harley-Davidson of Santa Clarita.
- Robert Patrick and Kristanna Loken both played ruthless terminators in Terminator 2 : Le Jugement dernier (1991) and Terminator 3 : Le Soulèvement des machines (2003) (respectively) and would later co-star in S.W.A.T. 2: Firefight (2011).
- In the mid to late 1980s, he lived in the same Los Angeles complex with such neighbors such as Jim Carrey (Bruce tout-puissant (2003)), Ernie Hudson (S.O.S. fantômes (1984)) and Cynthia Ettinger (Deadwood (2004), Le silence des agneaux (1991)).
- Has four siblings: Richard Patrick, Cheri Patrick, Karen Patrick and Lewis Patrick.
- Has two children with his wife Barbara Patrick: daughter Austin and son Samuel.
- Brother-in-law of Tina Johnson.
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Terminator 2 : Le Jugement dernier (1991) and Spy Kids (2001).
- He is the son of Violet Nadine (Hammond) and Robert Merle Patrick. His father was from Winthrop, Suffolk, Massachusetts. His mother was from Arkansas. He has deep roots in both the American South and New England (the latter including Vermont, New Hampshire, and Maine).
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