15 wins & 40 nominations
- 1999 Winner Blockbuster Entertainment Award
- Favorite Supporting Actress - Comedy/Romance
- 1997 Winner Blockbuster Entertainment Award
- Favorite Supporting Actress - Romance
- 2005 Winner Daytime Emmy
- Outstanding Performer in a Children/Youth/Family Special
For playing: "Anne".
- 2005 Nominee Primetime Emmy
- Outstanding Supporting Actress in a Drama Series
For playing: "Abbey Bartlet". - 2004 Nominee Primetime Emmy
- Outstanding Supporting Actress in a Drama Series
For playing "Abbey Bartlet". - 2003 Nominee Primetime Emmy
- Outstanding Supporting Actress in a Drama Series
For playing: "Abbey Bartlet". - 2002 Winner Primetime Emmy
- Outstanding Supporting Actress in a Drama Series
For playing: "Abbey Bartlet".
- 1975 Nominee Golden Apple
- Female New Star of the Year
- 1999 Nominee Golden Globe
- Best Performance by an Actress in a Miniseries or Motion Picture Made for Television
- 1994 Nominee Golden Globe
- Best Performance by an Actress in a Motion Picture - Comedy or Musical
- 2003 Nominee Golden Satellite Award
- Best Actress in a Miniseries or a Motion Picture Made for Television
- 1997 Nominee Golden Satellite Award
- Best Actress in a Supporting Role in a Motion Picture, Drama
- 1996 Winner NBR Award
- Best Acting by an Ensemble
Shared with: Bette Midler · Goldie Hawn · Diane Keaton · Maggie Smith · Dan Hedaya · Sarah Jessica Parker · Victor Garber · Stephen Collins · Elizabeth Berkley · Marcia Gay Harden · Bronson Pinchot · Jennifer Dundas · Eileen Heckart · Philip Bosco · Rob Reiner · James Naughton · Ari Greenberg · Aida Linares
- 1979 Winner People's Choice Award
- Favorite Motion Picture Supporting Actress
- 1976 Nominee Gold Medal
- Favorite Female Newcomer
- 2005 Nominee Actor
- Outstanding Performance by an Ensemble in a Drama Series
Shared with: Kristin Chenoweth · Dulé Hill · Allison Janney · Joshua Malina · Mary McCormack · Janel Moloney · Richard Schiff · Martin Sheen · John Spencer · Lily Tomlin · Bradley Whitford - 2004 Nominee Actor
- Outstanding Performance by an Ensemble in a Drama Series
Shared with: Dulé Hill · Allison Janney · Joshua Malina · Janel Moloney · Richard Schiff · Martin Sheen · John Spencer · Bradley Whitford - 2003 Winner Actor
- Outstanding Performance by a Female Actor in a Television Movie or Miniseries
- 2003 Nominee Actor
- Outstanding Performance by an Ensemble in a Drama Series
Shared with: Dulé Hill · Allison Janney · Rob Lowe · Joshua Malina · Janel Moloney · Mary-Louise Parker · Richard Schiff · Martin Sheen · John Spencer · Lily Tomlin · Bradley Whitford
- 2002 Nominee OFTA Television Award
- Best Actress in a Motion Picture or Miniseries
- 2010 Nominee Gold Derby TV Award
- TV Movie/Mini Supporting Actress of the Decade
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