- His first wife, Jane, died in a car crash in 1995. This was devastating to him because after all the turmoil during their divorce, they had become friends. This friendship began when they both had to put up a brave face at a premiere for their son, Josh Brolin.
- Screen-tested for the role of James Bond in Octopussy (1983), but was ruled out when Roger Moore agreed to reprise the role.
- His acting mentor was the late Robert Young.
- Stepfather of Jason Gould. (Brolin co-starred with Gould's biological father Elliott Gould in Capricorn One (1978), 21 years before he married Gould's biological mother Barbra Streisand).
- Best known by the public for his role as Dr. Steven Kiley in Docteur Marcus Welby (1969), and for his starring role as Peter MacDermott in Hôtel (1983).
- Was attached to play Colonel Samuel Trautman in John Rambo (2008) after Richard Crenna died, but the role was written out of the script.
- Has English, German, Irish, Scottish, and Swiss-German ancestry. His family surname, Bruderlin, originates in Switzerland, and his mother's Mansur line traces back to England.
- Not only was he a pro race car driver, he also has a pilot's license.
- Acted in a make-up test for La planète des singes (1968) as "Cornelius," the chimpanzee scientist later portrayed in the final version of the film by Roddy McDowall.
- Resides with wife Barbra Streisand on a three-acre oceanfront property in Malibu, CA.
- Has a younger brother and two younger sisters.
- He was awarded a Star on the Hollywood Walk of Fame for Television at 7030 Hollywood Boulevard in Hollywood, California on August 27, 1998.
- Son of Helen Sue (Mansur), a housewife, and Henry Hurst Bruderlin.
- Grandfather of Trevor Brolin and Eden Brolin.
- Studied drama at the University of California Los Angeles before signing a contract with 20th Century Fox in 1960.
- Is a lifelong Democrat and supported John Kerry in the 2004 election.
- Son-in-law of Diana Kind.
- Campaigned for 2008 Democratic candidate Hillary Clinton for president.
- Starred in Enfer mécanique (1977) with Kyle Richards, whose birthday is January 11, 1969, which is a date mentioned in Pee-wee Big Adventure (1985) (January 11, 1974). The latter film also starred him towards the end.
- Mentioned in the sitcom episode Are You There God? It's Me, Peter (2018).
- The son of Helen Sue (née Mansur) (1916-2014), a housewife, and Henry Hurst Bruderlin (1911-2002), a building contractor.
- Brolin costarred with two former football players-turned actors: Rosey Grier in "Skyjacked" and O.J. Simpson in "Capricorn One".
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