- He was born in New York City. He comes from a creative, arts-involved family. His Irish-American mother, Katherine Healy, was a music teacher and poet, and his Italian-American father, Armand Anthony Assante Sr., was a painter and artist.
- Christopher Reeve was scheduled to play the lead role in Kidnapped (1995); Armand replaced him following Reeve's paralyzing horse-riding accident.
- Lives on a farm in upstate New York, he has been separated from wife Karen since 1994 and has two daughters, Anya and Alessandra.
- Has twice played Sylvester Stallone's brother in La taverne de l'enfer (1978) and Judge Dredd (1995).
- Reportedly gained nearly 50 lbs for his role as John Gotti in Gotti (1996).
- Alumnus of the AADA (American Academy of Dramatic Arts), Class of 1969.
- Attended and graduated from Cornwall Central High School in upstate New York.
- Friends with Jennifer Blanc-Biehn since they filmed The Third Wish (2005).
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