- Is one of the few cast members of Lost : Les Disparus (2004) who did not have to audition, because his former collaborator (from Alias (2001)) J.J. Abrams thought of O'Quinn for the part of Locke before the actor was even offered it.
- He is one of eleven children.
- Actually learned how to properly throw and handle knives for his role on Lost : Les Disparus (2004).
- Not many know that he is a talented guitarist and singer. He is a particularly big fan of Neil Young and can apparently do a dead-on impression of him.
- Although always friendly onset, he keeps private and mysterious habits apart from his younger Lost : Les Disparus (2004) co-stars, who often get together for wild parties when not shooting. He keeps this enigmatic aura so they will regard him similarly to the way they regard his mysterious character Locke.
- Has been balding since his early 20s and has appeared with a partially or entirely shaved head in most of his films.
- Has had roles in both of J.J. Abrams's hit television series Alias (2001) and Lost : Les Disparus (2004).
- He elongated his last name to "O'Quinn" from his real name of "Quinn" to distinguish himself from another person named Terry Quinn already acting in films.
- In an episode of Lost : Les Disparus (2004), his character Locke's parents were played by Kevin Tighe and Swoosie Kurtz, who are both only eight years O'Quinn's senior.
- Is good friends with 1013 Productions' Chris Carter, having appeared in most of his work: as a guest star in two episodes of X-Files : Aux frontières du réel (1993), a supporting role in The X-Files, le film : Combattre le futur (1998) and recurring roles on Harsh Realm (1999) and Millennium (1996).
- Attended and graduated from the University of Iowa in Iowa City, Iowa.
- Has an Irish Terrier named Reggie.
- Has been experienced in percussion since high school.
- Grew up in Newberry, Michigan and was raised Roman Catholic.
- Attended and graduated from Central Michigan University in Mount Pleasant, Michigan.
- Has two sons: Oliver Quinn (b. 1984) and Hunter Quinn (b. 1986).
- Has English and Irish ancestry.
- His brother Thomas Anthony Quinn is also an actor, who acts and teaches theatre in central Illinois.
- Has appeared in episodes of two different series with the same name. Both Millennium (1996) and Lost : Les Disparus (2004) have had episodes featuring O'Quinn called "Walkabout".
- Although he played Chris Nash's father in Mischief (1985), he is only nine years his senior in real life.
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