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Carriers is based on a screenplay written by co-directors Àlex and David Pastor.

Post-apocalyptic movies are popular topics and have been so for over 60 years. Some, like Carriers, feature viruses, e.g.. L'ultimo uomo della Terra (1964) (1964) and its variants 1975: occhi bianchi sul pianeta Terra (1971) (1971) and Io sono leggenda (2007) (2007). Viruses also destroy the world in L'ombra dello scorpione (1994) (1994), 28 giorni dopo (2002) (2002)—and its sequel 28 settimane dopo (2007) (2007)—Benvenuti a Zombieland (2009) (2009), The Dead Outside (2008) (2008), and Resident Evil (2002) (2002) and its sequels Resident Evil: Apocalypse (2004) (2004), Resident Evil: Extinction (2007) (2007), Resident Evil: Afterlife (2010) (2010), Resident Evil: Retribution (2012) (2012), and Resident Evil: The Final Chapter (2016) (2016). Other apocalyptic movies center around atomic or nuclear disasters such as L'ultima spiaggia (1959) (1959), Il pianeta delle scimmie (1968) (1968), Apocalypse 2024 - Un ragazzo, un cane, due inseparabili amici (1975) (1975), The Day After - Il giorno dopo (1983) (1983), Testament (1983) (1983), L'uomo del giorno dopo (1997) (1997), and Deadland (2009) (2009). Global warming is the culprit in The Day After Tomorrow - L'alba del giorno dopo (2004) (2004), solar flares in Dove sono gli altri? (1974) (1974), and solar storms cause global warming in 2012 (2009) (2009). In La notte della cometa (1984) (1984), it's a comet of course; in E venne il giorno (2008) (2008), it's plant toxins; and in Waterworld (1995) (1995), the polar ice caps have melted and most of Earth is underwater. In Blindness - Cecità (2008) (2008), an inexplicable case of white blindness sends a city into chaos; and in La terra silenziosa (1985) (1985), it's a government research project named "Project Flashlight" that goes awry. The TV series Jericho (2006) (2006-2008) blames the apocalypse on terrorist attacks, and in Planet Terror (2007) (2007) an experimental bio-nerve gas turns everyone into zombies. The villain is cyber-intelligence in The Matrix trilogy—Matrix (1999) (1999), Matrix Reloaded (2003) (2003), and Matrix Revolutions (2003) (2003). Still other movies, such as Codice Genesi (2010) (2010) and The Road (2009) (2009) cite no cause, simply showing how people try to survive after an apocalypse. The TV series I sopravvissuti (1975) (1975-1977), Jeremiah (2002) (2002-2004), Survivors (2008) (2008-2010) and The Strain (2014) (2014–) all deal with viral outbreaks and societal collapse.

Carriers was at first rated R in its uncut version in the states and, before the theatrical release, was cut to a financially more promising PG-13 rating by Motion Picture Association of America (MPAA) typically removing some harsh language and several seconds resp. frames of rather bloody shots or, if necessary, replaced by more harmless alternative footage. In the US, only the edited PG-13 theatrical version was released on DVD and Blu-ray disc as well, while, as is known, the original uncut version was released in all of Europe.