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The role of Romeo was originally intended for WWE wrestler "Stone Cold" Steve Austin. However, without notifying Austin, his agent turned down the offer of $55,000 to star in the film. The role was subsequently offered to WCW star Bill Goldberg, who accepted the role, for a fee of $250,000. When Austin found out about this, he expressed his anger to Vince McMahon for not letting him know about the movie offer.

Ally Walker didn't reprise her role as Veronica Roberts, due to the scheduling conflicts while she was filming the series Profiler - intuizioni mortali (1996).

Michael Jai White (S.E.T.H.) also appeared in the original I nuovi eroi (1992) as a soldier.

Last feature film of Kiana Tom. Being an athlete and fitness model, she had no desire to pursue a career as a full-time actress, combined with eventually getting married in 2002 and having kids, therefore focusing on motherhood.

Due to the film's critical and financial failure, subsequent Universal Soldier entries ignore the events of this film and outright contradict it in several ways. While still an official entry, it is no longer considered canon.