Zoe Perry is the real-life daughter of Laurie Metcalf from The Big Bang Theory (2007). Over 20 years earlier, she also played the younger version of her mother in episodes 5.7, Halloween IV (1992) and 7.19, All About Rosey (1995) of Pappa e ciccia (1988). Now, she again plays a younger version of her mother's character over 20 years later.
Iain Armitage (Young Sheldon) said he was committed to his role of Sheldon thanks to Jim Parsons (Adult Sheldon) coaching him and explaining who Sheldon is.
When the show started, some of the crew were shocked at how much Zoe Perry looked and sounded like Laurie Metcalf and were surprised when she told them it was genetic since Laurie is her mom.
Lance Barber, who plays George Cooper Sr, is the same actor who played Jimmy Speckerman, Leonard's (Johnny Galecki) high-school bully in one episode of The Big Bang Theory (2007) in 2011.
Sheldon once had a nightmare about a pool monster. The pool monster was voiced by none other than Kaley Cuoco