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After failing to earn a callback audition for host of The Toronto Show (2003), Ennis was coincidentally booked to host a stand-up comedy show that featured a network showcase for potential series hosts. He was informed halfway through the evening that he was winning over the network heads, and he went on to land the gig, hosting 120 episodes of the late-night comedy and music series.

The part of Rich Dotcom from Blindspot (2015) was written especially for him.

Ennis's musical comedy group, Calcu-Lator and the Oral Presentation, were nominated for the prestigious Tim Sims Award in 2003.

Contributing writer for the humour web-zine www.somethingspace.com

Credits Owen Wilson in Un colpo da dilettanti (1996) and Vince Vaughn in Swingers (1996)for inspiring him into his career with their improvisational style in those films.

Has stated often that his favorite song, for a party or the summer, is Billy Ocean's Lover Boy, which also had a high-profile place on the soundtrack to Red Oaks (2014).

Is of Turkish descent.