- Son of actor/director Vittorio De Sica and actress María Mercader, father of actor Brando De Sica, younger brother of composer Manuel De Sica, uncle of assistant director Andrea De Sica, brother-in-law of actor/director Carlo Verdone. Nephew of Ramón Mercader. Half-brother of Emilia De Sica.
- Considering Marlon Brando his favorite actor, he named his first son Brando De Sica.
- Dated Isabella Rossellini when she was 17 and he was 18.
- Brother-in-law of actor/director Carlo Verdone and Maria Lucia Langella. Former brother-in-law of Tilde Corsi.
- Studied at the University La Sapienza in Rome.
- Although participating at Festival di Sanremo (1951) in 1973, he didn't continue a career as singer.
- Uncle of assistant director Andrea De Sica. Uncle-in-law of Paolo and Giulia Verdone.
- Injured by a firecracker on New Year's eve. (31 dicembre 1999)
- Has one son, Brando De Sica, and one daughter, Mariarosa.
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