- Daniel Day-Lewis was so impressed by his work in the film La storia di Jack e Rose (2005) that he suggested him to Paul Thomas Anderson for the role of Paul Sunday in the film Il petroliere (2007).
- He has appeared in four films that have been nominated for the Best Picture Oscar: Little Miss Sunshine (2006), Il petroliere (2007), 12 anni schiavo (2013) and The Fabelmans (2022). 12 Years a Slave won in the category.
- Packed on 20 lbs. of muscle to play real-life convicted murderer and escapee David Sweat in the TV series Escape at Dannemora (2018).
- Matt Reeves wrote his part of The Riddler in The Batman (2022) with him in mind.
- Made his Broadway debut at the age of 12 in "Inherit The Wind" opposite George C. Scott and Charles Durning.
- Lead guitar and vocals in the band Mook, based out of Wilton, Connecticut.
- Has worked with five directors that have won a Best Director Oscar: Ang Lee, Bong Joon-ho, Daniel Scheinert, Daniel Kwan, and Steven Spielberg.
- Paul's paternal grandparents, John Dano and Anna Herzo, were both from Rusyn/Carpathian families that immigrated to Scranton, Pennsylvania. Paul's mother is of Slovenian/Bohemian Czech descent on one side and Swedish descent on the other.
- He has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically significant: 12 anni schiavo (2013).
- Father is a financial advisor, mother is a homemaker.
- Was ranked #5 on Entertainment Weekly's 30 Under 30, the Actors List. (2008)
- He and Billy Kay were already friends at the time L.I.E. (2001) was filmed, having worked together on an earlier film, (The Newcomers (2000)).
- No relation to actor Royal Dano.
- Graduated from high school on 22 June 2002.
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