- When a publicity photo of Guest and his co-stars from This Is Spinal Tap (1984) ran in Rolling Stone magazine, Jamie Lee Curtis saw the picture, fell in love and gave her phone number to Guest's agent. They dated and eventually married.
- When he went to pick up his Tesla car with wife Jamie Lee Curtis, the technician instructed them to check out the air conditioning and audio controls, each of which maxed out at "11." Apparently Tesla CEO Elon Musk was a huge fan of the film This Is Spinal Tap (1984) and had the controls exclusively customized for the couple.
- Guest became the 5th Baron Haden-Guest, of Saling in the County of Essex, when his father died in 1996.
- He has been a skilled guitarist since the 1960s and has displayed his talents in both Spinal Tap projects and A Mighty Wind (2003). He actually became acquainted with frequent co-stars and on-screen band mates Michael McKean and Harry Shearer at music venues before the three decided to make a career as comedic actors.
- Christopher's father, Peter Haden-Guest, was a British hereditary lord, an actor, and a dancer, who ended up a UN diplomat. Christopher's father's family was a mix of English, Dutch Jewish, German Jewish, and Scottish ancestry (including distant American-born ancestors). Christopher's mother, Jean Pauline (Hindes), was the daughter of Russian Jewish immigrants.
- His idol growing up was comedian Peter Sellers.
- Christopher dropped the Haden from his surname when he started going to acting auditions in his 20s; he thought it sounded long-winded and distracting.
- In 2005, announced his intention to stop making mockumentary films, because he doesn't find them funny anymore.
- Older brother of actor Nicholas Guest, who is heir presumptive to the family title. (As Christopher's children are adopted, they cannot inherit the barony).
- Son-in-law of Tony Curtis and Janet Leigh.
- Attended the House of Lords regularly until the passage of the House of Lords Act 1999 barred most hereditary peers from their seats.
- Was introduced to his future wife, Jamie Lee Curtis, by her Halloween II co-star, Leo Rossi, at a mutual celebrity softball league.
- His character from This Is Spinal Tap (1984), Nigel Tuffnel, is partially a spoof of British rocker Jeff Beck
- He has appeared in four films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Anche i dottori ce l'hanno (1971), Girl friends (1978), This Is Spinal Tap (1984) and La storia fantastica (1987).
- The five films that most influenced the director Christopher Guest: La strada (1954) - Federico Fellini, Il dottor Stranamore - Ovvero: come ho imparato a non preoccuparmi e ad amare la bomba (1964) - Stanley Kubrick, Broadway Danny Rose (1984) - Woody Allen, Cul de sac (1966) - Roman Polanski, La palla n° 13 (1924) - Buster Keaton.
- Guest shoots 10-minute scenes to let the improvisations unfold organically and ends up with about 60 hours of film, which is then edited down over a year and a half to 90 minutes.
- Half-brother of journalist Anthony Haden-Guest, the bibulous English socialite and journalist satirized by Tom Wolfe in Il falò delle vanità (1990).
- Has two adopted children: daughters Annie Guest (born in December 1986) and Ruby Guest (born in March 1996). Under the terms of the letters patent that created the Barony of Haden-Guest, they cannot inherit the title, but they can use the courtesy title of the Honourable before their first names.
- During an interview with his wife Jamie Lee Curtis, on The Graham Norton Show (2007), she mentions that he drives a Tesla with both the volume and Air Con dials going all the way up to 11.
- Alumnus of Stella Adler Studio of Acting.
- He is a seventh cousin of French actor Jean-Pierre Aumont. They both descend from Abraham Casper de Vries Rofe and Marianne Asser-Shochet, who were Dutch Jews.
- Brother-in-law of actress Kelly Curtis and Pamela Guest.
- Was the muse for an Asian-American short comedic film entitled Pax Importi Modellus: The Rise of the Import Model (2004), which has gained international attention.
- Uncle of Elizabeth Guest and Julia Guest.
- Lived in New York in the 1960s.
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