- He is nearly a foot taller than his father John Cassavetes. He got his height from his mother's (Gena Rowlands) side of the family.
- Considers Le pagine della nostra vita (2004) his worst film.
- Is a gifted speed-reader.
- Older brother of actors Xan Cassavetes and Zoe R. Cassavetes.
- Grandson of Katherine Cassavetes and Lady Rowlands.
- Met Heather Wahlquist shortly before filming John Q (2002). While on set, they fell in love and got engaged one month later. They have one child together.
- Was in negotiations to write a screenplay for a remake of his father's film, L'assassinio di un allibratore cinese (1976) for New Line Cinema with Brett Ratner set to direct in 1998. The project never got made because Ratner made The Family Man (2000) instead.
- Alumnus of the AADA (American Academy of Dramatic Arts), Class of 1980.
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