- Longtime companion of Marjorie Main.
- In August 1955, she began flying lessons in Glendale, California; but the studio made her stop because of insurance problems.
- Acquired a small coffee plantation in South America in her later years.
- Following her death in 1971, her body was donated for medical research.
- She and Lionel Barrymore played wife and husband in Ah, Wilderness! (1935). Three years later, they played daughter and father in L'eterna illusione (1938).
- Spring and Lionel Barrymore were initially cast as Ma and Pa Hardy in the Andy Hardy film series starring Mickey Rooney. However, Metro-Goldwyn-Mayer decided to replace the couple with Fay Holden and Lewis Stone before the series started.
- She was a lifelong science fiction fan, and appeared in print ads for The Magazine of Fantasy and Science Fiction at the height of her TV popularity.
- Acting mentor and friends with Harry Morgan.
- Became a grandmother for the 1st time at age 55 when her daughter Lois gave birth to a son, James Alexander Graham on October 30, 1941.
- She was awarded 2 Stars on the Hollywood Walk of Fame for Motion Picture at 6507 Hollywood Boulevard; and for Television at 6231 Hollywood Boulevard in Hollywood, California.
- She performed in reference footage for Walt Disney's La bella addormentata nel bosco (1959).
- Biography in "Actresses of a Certain Character: Forty Familiar Hollywood Faces from the Thirties to the Fifties" by Axel Nissen.
- Gave birth to her 2nd child, a daughter Lois Chandler, with her husband Roy Carey Chandler (1917).
- Met Harry Morgan on the set of the period drama Il castello di Dragonwyck (1946). Eight years later, he would co-star opposite Byington on December Bride (1954).
- Gave birth to her 1st child, a daughter Phyllis Chandler, with her husband Roy Carey Chandler (1916).
- Became a grandmother for the 2nd time at age 62 when her daughter Phyllis gave birth to a daughter, Christine Helene Baxley, on May 6, 1949.
- Appears in two Oscar Best Picture winners: La tragedia del Bounty (1935) and L'eterna illusione (1938), and four other nominees: Piccole donne (1933), Infedeltà (1936), Figlia del vento (1938) and Il cielo può attendere (1943).
- Daughter of Edwin Lee (1852-1891) and Helene Maud (née Cleghorn) Byington (1862-1907).
- Name checked in The Trouble with Trillions (1998), when Mr Burns says to Homer: "Well, of course, I didn't want a racehorse in my living room. But you don't say no to Spring Byington, do you?".
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