- Was the first actor to win a Golden Globe for both TV Drama and TV Comedy and is still one of only two actors to accomplish the feat (Kelsey Grammer joined him in 2012).
- Filed a $25 million lawsuit against the producers and syndicators of X-Files (1993) alleging he has been cheated of his contractual share of profits from the series.
- Is a huge fan of Doctor Who (1963) and has expressed interest in appearing on the series as a villain.
- Speaks French, Hebrew and Latin.
- Very good friends with Nicholas Lea, who played his nemesis Alex Krycek on X-Files (1993).
- Checked himself into a rehabilitation center seeking treatment for sex addiction. Completed rehab on October 7, 2008. On October 15, David announced that he and his wife Téa Leoni had been separated for several months. In 2009, the couple was seen together again. In interviews in the following months Duchovny revealed that they had reconciled. (agosto 2008)
- Loves dogs. Hated making the scene where agent Mulder was being mauled by a dog and forced to attack the dog for X-Files: Voglio crederci (2008).
- Made his film debut in Una donna in carriera (1988), as one of the guests hiding in the bathroom at Tess McGill's surprise birthday party.
- David's paternal grandfather, Moshe Duchovny, was a Jewish immigrant from Berdychiv (now in Ukraine, and part of the Russian Empire when he immigrated), while David's paternal grandmother was a Polish Jewish immigrant. David's father, Amram Ducovny, was a Brooklyn-born publicist for the American Jewish Commitee; he died on 23 August 2003 from heart disease. David's mother, Margaret (Miller), is a Lutheran immigrant from Scotland. David has a brother, Daniel Ducovny, a sister, Laurie Birnbaum, and a stepbrother, Jonathan Sahula. Duchovny mean primarily 'spiritual' in Russian, but it can also mean 'otherworldly' or 'ghostly'.
- His mother taught at Grace Church School in New York City and had a portion the building named after her when she retired.
- Had played scholarship-level basketball during some of his high school and college career. Had an accident while playing basketball in high school which damaged his right eye.
- While at Yale University, he was classmates with Jennifer Beals, whom Duchovny suggested for a role on X-Files (1993) (which eventually went to Gillian Anderson).
- Has an allergic reaction to metal which prevents him from wearing his wedding ring at times.
- Birthday is two days before X-Files (1993) co-star Gillian Anderson. He is eight years her senior.
- Was ABD ("All But Dissertation") when he left Yale University, so he never actually received his graduate degree. The title of his uncompleted doctoral thesis was "Magic and Technology in Contemporary Poetry and Prose".
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6508 Hollywood Boulevard in Hollywood, California on January 25, 2016.
- First celebrity guest to appear on the television premiere of The Late Late Show with Craig Ferguson (2005) (January 3, 2005).
- Has played the same character (Fox Mulder) on five different series: X-Files (1993), Fl-eek Stravaganza (1992), I Simpson (1989), The Lone Gunmen (2001) and Millennium (1996) (also from Chris Carter).
- Was best man at Mitch Pileggi's second wedding.
- Was partially responsible for moving the filming of X-Files (1993) from Vancouver to California.
- Daughter West Duchovny born April 24, 1999, second child son Kyd Miller Duchovny born June 15, 2002.
- Started off by acting in soft porn films.
- He does a very good impersonation of Jeff Goldblum, as demonstrated during his appearance on Il Saturday Night Live (1975).
- Has appeared on the Celebrity edition of Who Wants to Be a Millionaire (1999) in 2000. He was the first celebrity in the hot seat. He answered 13 questions correctly giving him $250,000 for his charity. However, he then answered his $500,000 incorrectly resulting in a $218,000 loss and he left with $32,000.
- His last name means "spiritual" in Slovak and Czech languages.
- Chosen by People (USA) magazine as one of the 50 Most Beautiful People in the World (1996).
- Childhood friends with Jason Beghe. When he married Téa Leoni, Beghe was his best man.
- Is the only cast member of X-Files (1993) to host Il Saturday Night Live (1975).
- His last name (spelled as: duchowny) means "a clergyman" in Polish.
- Is a die-hard fan of the New York Yankees.
- Was the subject of the song "David Duchovny" by Bree Sharp.
- Former boyfriend of Maggie Wheeler.
- He kept three dogs and four cats as a child.
- Celebrated his 10th birthday on Erraid, a small island off the west coast of Scotland.
- His father who was a public relations executive and his mother,Meg split when he was 11.
- Former boyfriend of Perrey Reeves.
- Is known to be a huge sports fan, and has appeared on MTV's "Rock n' Jock Softball Game".
- Friends with actor Ron Eldard.
- Endorsed Kamala Harris for president in 2024.
- Stayed in 411 Witherspoon Hall his freshman year at Princeton University.
- Uncle of twin boys Gabriel and Luca (born May 2004), sons of his sister Laurie and brother-in-law Michael Birnbaum.
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