- Born Marco Giuseppe Salussolia in London to an Italian father and an Austrian mother.
- Close friends with Daniel Craig. Craig is also the godfather of one of Strong's sons.
- He can speak fluent German.
- Has appeared in five films with Colin Firth: Febbre a 90° (1997), La talpa (2011), Before I Go to Sleep (2014), Kingsman: Secret Service (2014), and Kingsman: Il cerchio d'oro (2017).
- He was nominated for a 2003 Laurence Olivier Theatre Award for Best Performance in a Supporting Role of 2002 for his performance in "Twelfth Night", performed at the Donmar Warehouse.
- Lost his hair in his mid-twenties.
- Seems to have a passion for espionage movies as he has portrayed secret service agents on numerous occasions: He was the head of Jordanian secret intelligence in Nessuna verità (2008), a cold war era MI-6 agent in La talpa (2011), a CIA agent in Zero Dark Thirty (2012), the chief of WWII era British Secret Intelligence Service in The Imitation Game (2014), a non-governmental secret service operative in Kingsman: Secret Service (2014) and Kingsman: Il cerchio d'oro (2017), and a retired MI-6 assassin in Grimsby - Attenti a quell'altro (2016). He also played a semi-retired MI-6 agent in 2018 television mini-series Deep State (2018).
- Won the 2015 Olivier Award for Best Actor for A View From The Bridge for which he also won the Critics Circle Award. He was also nominated for the Tony Award and won the Theatre World award for the same performance on Broadway.
- He was nominated for an Olivier Award for Best supporting Actor for his performance in Uncle Vanya at the Donmar Warehouse (London) in 2002.
- He got down to the last two spots for the role of Anton Chigurh in Non è un paese per vecchi (2007). Originally turned down Nessuna verità (2008) because his wife was pregnant with their second child.
- As of 2023, he has appeared in four films that were nominated for the Best Picture Oscar: Zero Dark Thirty (2012), The Imitation Game (2014), 1917 (2019) and Tár (2022).
- Mark is the voice of the UK's National Health Service (NHS) and UK Government Coronavirus advertisements.
- Has two sons with Liza Marshall: Gabriel Strong and Roman Strong (b. October 5, 2007).
- He grew up in Myddleton Square, Kensington, London.
- Has appeared in two films under the same title: Sunshine - Storia di una famiglia (1999) and Sunshine (2007).
- His theatre break was in 'Napoli Milionaria' at the National Theatre and his television break in 'Our Friends in the North'.
- Has appeared in two films where the lead male character is named "Tristan": Tristano & Isotta (2006) and Stardust (2007).
- Was set to replace Javier Bardem for No Country For Old Men (2007) due to the latter initially being unavailable.
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